Polypharmacology in drug discovery /
"Covers the two-sided nature of polypharmacology--its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes. Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal arti...
| Άλλοι συγγραφείς: | |
|---|---|
| Μορφή: | Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Hoboken, N.J. :
Wiley,
[2012]
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| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Frontmatter
- Color Plates
- Introduction: The Case for Polypharmacology / Andrew L Hopkins
- Polypharmacology: A Safety Concern in Drug Discovery. The Relevance of Off-Target Polypharmacology / Bruce D Car
- Screening for Safety-Relevant Off-Target Activities / Laszlo Urban, Steven Whitebread, Jacques Hamon, Dmitri Mikhailov, Kamal Azzaoui
- Pharmacological Promiscuity and Molecular Properties / Jens-Uwe Peters
- Kinases as Antitargets in Genotoxicity / Stephan Kirchner
- Activity at Cardiovascular Ion Channels: A Key Issue for Drug Discovery / Ian M Bell, Mark T Bilodeau, Armando A Lagrutta
- Prediction of Side Effects Based on Fingerprint Profiling and Data Mining / Jacques Migeon
- Polypharmacology: An Opportunity for Drug Discovery. Polypharmacological Drugs: ₃Magic Shotguns₄ for Psychiatric Diseases / Wesley K Kroeze, Bryan L Roth
- Polypharmacological Kinase Inhibitors: New Hopes for Cancer Therapy / Annalisa Petrelli
- Polypharmacology as an Emerging Trend in Antibacterial Discovery / Lynn L Silver
- A ₃Magic Shotgun₄ Perspective on Anticonvulsant Mechanisms / Matt T Bianchi, Kathy Chuang
- Selective Optimization of Side Activities (SOSA): A Promising way for Drug Discovery / Thierry Langer, Camille-Georges Wermuth
- Selected Approaches to Polypharmacological Drug Discovery. Selective Multitargeted Drugs / Richard Morphy
- Computational Multitarget Drug Discovery / Jeremy A Horst, Adrian Laurenzi, Brady Bernard, Ram Samudrala
- Behavior-Based Screening as an Approach to Polypharmacological Ligands / Dani Brunner, Vadim Alexandrov, Barbara Caldarone, Taleen Hanania, David Lowe, Jeff Schneider, Jayaraman Chandrasekhar
- Multicomponent Therapeutics / Alexis A Borisy, Grant R Zimmermann, Joseph Leh̀r
- Case Studies. Discovery of Sunitinib as a Multitarget Treatment of Cancer / Catherine Delbaldo, Camelia Colichi, Marie-Paule Sablin, Chantal Dreyer, Bertrand Billemont, Sandrine Faivre, Eric Raymond
- Antipsychotics / Claus Riemer
- Triple-Uptake Inhibitors (Broad-Spectrum Antidepressants) / Phil Skolnick
- Therapeutic Potential of Small Molecules Modulating the Cyclooxygenase₆5-Lipoxygenase Pathway / Wolfgang Albrecht, Stefan Laufer
- Drug Research Leading to Imatinib and beyond to Nilotinib / Paul W Manley, Jorg Zimmermann
- Towards Antimalarial Hybrid Drugs / Bernard Meunier
- Multitargeted Drugs for Treatment of Alzheimer's Disease / Andrea Cavalli, Maria Laura Bolognesi
- Carbonic Anhydrases: Off Targets, Add-On Activities, or Emerging Novel Targets? / Claudiu T Supuran
- Index.
