Cancer as a metabolic disease : on the origin, management, and prevention of cancer /
The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of ca...
| Κύριος συγγραφέας: | |
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| Μορφή: | Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Hoboken :
John Wiley & Sons,
2012.
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| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Cancer as a Metabolic Disease; Contents; Foreword; Preface; 1. Images of Cancer; How Cancer is Viewed; References; 2. Confusion Surrounds the Origin of Cancer; The Oncogenic Paradox; Hallmarks of Cancer; Reassessment; References; 3. Cancer Models; Problems with Some Cancer Models; Animal Charges as a Major Impediment to Cancer Research; Problems with Tumor Histological Classification; Personal Perspective on Cancer; References; 4. Energetics of Normal Cells and Cancer Cells; Metabolic Homeostasis; The Constancy of the D G'ATP; ATP Production in Normal Cells and Tumor Cells.
- Energy Production Through Glucose Fermentation; Glutaminolysis with or without Lactate Production; Transamination Reactions; TCA Cycle, Substrate-Level Phosphorylation; Cholesterol Synthesis and Hypoxia; Summary; References; 5. Respiratory Dysfunction in Cancer Cells; Normal Mitochondria; Morphological Defects in Tumor Cell Mitochondria; Proteomic Abnormalities in Tumor Cell Mitochondria; Lipidomic Abnormalities in Tumor Cell Mitochondria; Cardiolipin: A Mitochondrial-Specific Lipid; Cardiolipin and Abnormal Energy Metabolism in Tumor Cells.
- Complicating Influence of the In Vitro Growth Environment on Cardiolipin Composition and Energy Metabolism; Mitochondrial Uncoupling and Cancer; Cancer Cell Heat Production and Uncoupled Mitochondria; Personal Perspective; Summary; References; 6. The Warburg Dispute; Sidney Weinhouse's Criticisms of the Warburg Theory; Alan Aisenberg's Criticisms of the Warburg Theory; Sidney Colowick's Assessment of the Aisenberg Monograph; Apples and Oranges; References; 7. Is Respiration Normal in Cancer Cells?; Pseudo-Respiration.
- How Strong is the Scientific Evidence Showing that Tumor Cells can Produce Energy Through OxPhos?; OxPhos Origin of ATP in Cancer Cells Reevaluated; What About OxPhos Expression in Other Tumors?; The Pedersen Review on Tumor Mitochondria and the Bioenergetics of Cancer Cells; References; 8. Is Mitochondrial Glutamine Fermentation a Missing Link in the Metabolic Theory of Cancer?; Amino Acid Fermentation can Maintain Cellular Energy Homeostasis During Anoxia; Evidence Suggesting that Metastatic Mouse Cells Derive Energy from Glutamine Fermentation.
- Fermentation Energy Pathways can Drive Cancer Cell Viability Under Hypoxia; Competing Explanations for the Metabolic Origin of Cancer; Chapter Summary; References; 9. Genes, Respiration, Viruses, and Cancer; Does Cancer have a Genetic Origin?; Respiratory Insufficiency as the Origin of Cancer; Germline Mutations, Damaged Respiration, and Cancer; Somatic Mutations and Cancer; Revisiting the Oncogene Theory; Mitochondrial Mutations and the Absence or Presence of Cancer; Viral Infection, Damaged Respiration, and the Origin of Cancer; Summary; References.
- 10. Respiratory Insufficiency, the Retrograde Response, and the Origin of Cancer.
