Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations : Principles, Methods, and Applications in the Pharmaceutical Industry /
The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceuticascience physiologicallyly-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but without one dedicated book that provides the infor...
Κύριος συγγραφέας: | |
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Μορφή: | Ηλ. βιβλίο |
Γλώσσα: | English |
Έκδοση: |
Hoboken, N.J. :
Wiley,
[2011]
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Θέματα: | |
Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Modelling in the pharmaceutical industry
- Physiologically-based modelling
- A review of pharmacokinetic principles
- Physiological model for absorption
- Physiological model for distribution
- Physiological models for drug metabolism and excretion
- Generic whole-body physiologically-based pharmacokinetic modelling
- Variability, uncertainty and sensitivity analysis
- Evaluation of drug-drug interaction risk with pbpk models
- PBPK of biotherapeutics
- Data integration and sensitivity analysis
- Hypothesis generation and pharmacokinetic predictions
- Integration of PBPK and pharmacodynamics
- PBPK modelling of populations
- PBPK models along the drug discovery and development value chain.