Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations : Principles, Methods, and Applications in the Pharmaceutical Industry /

• Main Author: Peters, Sheila Annie
• Format: eBook
• Language: English
• Published: Hoboken, N.J. : Wiley, [2011]
• Subjects: Pharmacokinetics > Mathematical models.; Drugs > Design > Mathematical models.; Pharmacokinetics.; Drug Design.; Models, Biological.; Medicine.; Pharmacy.; MEDICAL > Pharmacology.; Electronic books.

The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceuticascience physiologicallyly-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but without one dedicated book that provides the infor...

Table of Contents:

• Modelling in the pharmaceutical industry
• Physiologically-based modelling
• A review of pharmacokinetic principles
• Physiological model for absorption
• Physiological model for distribution
• Physiological models for drug metabolism and excretion
• Generic whole-body physiologically-based pharmacokinetic modelling
• Variability, uncertainty and sensitivity analysis
• Evaluation of drug-drug interaction risk with pbpk models
• PBPK of biotherapeutics
• Data integration and sensitivity analysis
• Hypothesis generation and pharmacokinetic predictions
• Integration of PBPK and pharmacodynamics
• PBPK modelling of populations
• PBPK models along the drug discovery and development value chain.