Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations : Principles, Methods, and Applications in the Pharmaceutical Industry /

The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceuticascience physiologicallyly-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but without one dedicated book that provides the infor...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριος συγγραφέας: Peters, Sheila Annie
Μορφή: Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Hoboken, N.J. : Wiley, [2011]
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
Πίνακας περιεχομένων:
  • Modelling in the pharmaceutical industry
  • Physiologically-based modelling
  • A review of pharmacokinetic principles
  • Physiological model for absorption
  • Physiological model for distribution
  • Physiological models for drug metabolism and excretion
  • Generic whole-body physiologically-based pharmacokinetic modelling
  • Variability, uncertainty and sensitivity analysis
  • Evaluation of drug-drug interaction risk with pbpk models
  • PBPK of biotherapeutics
  • Data integration and sensitivity analysis
  • Hypothesis generation and pharmacokinetic predictions
  • Integration of PBPK and pharmacodynamics
  • PBPK modelling of populations
  • PBPK models along the drug discovery and development value chain.