Vaccinology : principles and practice /

• Άλλοι συγγραφείς: Morrow, John, 1949-
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken : John Wiley & Sons, 2012.
• Θέματα: Vaccines.; Drugs > Design.; Vaccination > Methods.; Medicine.; Pharmacy.; MEDICAL > Pharmacology.; Vaccination.; Electronic books.; Methods (Music)

 Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human applicationIncludes evaluation of vaccine efficacy and safetyDetails clinical trial design, including regulatory requirements. 

 Front Matter -- Introduction. Concept and Scope of Modern Vaccines / D Huw Davies, Clint S Schmidt, Nadeem A Sheikh -- Principles of Vaccine Design. Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants / Heather L Wilson, Scott Napper, George K Mutwiri, Sylvia van Drunen Littel-van den Hurk, Hugh Townsend, Lorne A Babiuk, Andrew A Potter, Volker Gerdts -- Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules / Antony N Antoniou, Izabela Lenart, David B Guiliano, Simon J Powis -- Understanding the Mucosal Immune System for Better Mucosal Vaccine Design / Janine Bilsborough, Joanne L Viney -- Immunologic Memory: T Cells in Humans / Maria Candela Iglesias, Victor Appay, Arnaud Moris -- Immunologic Memory: B cells / F Eun-Hyung Lee, Įaki Sanz -- Utility of Mouse Models in Vaccine Design and Development / Catharine M Bosio, Megan MacLeod, Philippa Marrack, Ross M Kedl -- Utility of Nonhuman Primate Models for Vaccines / Preston A Marx, Alexander F Voevodin -- Antigen Discovery. Sequence-Based Computational Approaches to Vaccine Discovery and Design / Darrick Carter -- Antigen Discovery for Vaccines Using High-Throughput Proteomic Screening Technologies / D Huw Davies -- Phage Libraries / Aaron K Sato -- Antigen Engineering. Attenuated Bacterial Vaccines / Richard W Titball, Helen S Atkins -- Virus-Like Particles as Antigen Scaffolds / Bryce Chackerian, John T Schiller -- Recombinant MVA vaccines: Optimization, Preclinical, and Product Development / Yper Hall, Miles W Carroll -- Recombinant Adenoviruses for Vaccination / Nelson Cesar Di Paolo, Dmitry Shayakhmetov, Andř Lieber -- Recombinant Avipoxviruses / Michael A Skinner, Stephen M Laidlaw -- Intracellular Facultative Bacterial Vectors for Cancer Immunotherapy / Patrick Guirnalda, Laurence Wood, Matthew Seavey, Yvonne Paterson -- Nucleic Acid Vaccination / Britta Wahren, Margaret A Liu -- Artificial Antigen-Presenting Cells: Large Multivalent Immunogens / Matthew F Mescher, Julie M Curtsinger -- Delivery Systems. Transcutaneous Immunization via Vaccine Patch Delivery System / Robert C Seid, Gregory M Glenn -- Needle-Free Jet Injection for Vaccine Administration / Brian R Sloat, Hoi K Tran, Zhengrong Cui -- Oral Vaccines: An Old Need and Some New Possibilities / Amit A Lugade, Kalathil Suresh, Yasmin Thanavala -- Adjuvants: From Serendipity to Rational Discovery / Derek T O'Hagan, Andreas Wack -- Immunostimulatory Properties of Biodegradable Microparticles / Fiona A Sharp, Ed C Lavelle -- Co-Administration of Co-Stimulatory Moieties / Carolina Arancibia-C̀rcamo, Yvette Latchman -- Toll Receptors in Relation to Adjuvant Effects / Dipshikha Chakravortty, Amit Lahiri, Priyanka Das -- Regulatory Considerations. Regulatory Issues (FDA and EMA) / Murrium Ahmad, Victoria Byers, Peter Wilson -- Evaluating Vaccine Efficacy. Immune Monitoring Design within the Developmental Pipeline for an Immunotherapeutic or Preventive Vaccine / Sylvia Janetzki, Pedro Romero, Mario Roederer, Diane L Bolton, Camilla Jandus -- Clinical Development Strategy: Nuts and Bolts / Candida Fratazzi, Claudio Carini -- Current Approaches to Identify and Evaluate Cancer Biomarkers for Patient Stratification / Robert Rees, Stephanie Laversin, Cliff Murray, Graham Ball -- Implementing Immunizations/Therapies. Mass Immunization Strategies / David L Heymann, R Bruce Aylward, Rudolf H Tangermann -- The Role of Mathematical Models in Vaccine Development and Public Health Decision Making / Marie-Claude Boily, Marc Brisson, Benoit Ḿsse, Roy M Anderson -- Vaccine Safety / John Iskander, Claudia Vellozzi, Jane Gidudu, Robert T Chen -- Index.