Analytical techniques for clinical chemistry : methods and applications /

• Άλλοι συγγραφείς: Caroli, Sergio, 1943-, Záray, Gyula
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken : Wiley, [2012]
• Θέματα: Clinical chemistry > Analysis.; Biochemistry.; Medicine.; MEDICAL > Immunology.; Electronic books.

 Discover how analytical chemistry supports the latest clinical research. This book details the role played by analytical chemistry in fostering clinical research. Readers will discover how a broad range of analytical techniques support all phases of clinical research, from early stages to the implementation of practical applications. Moreover, the contributing authors' careful step-by-step guidance enables readers to better understand standardized techniques and steer clear of everyday problems that can arise in the lab. Analytical Techniques for Clinical Chemistry opens with an overview of the legal and regulatory framework governing clinical lab analysis. Next, it details the latest progress in instrumentation and applications in such fields as biomonitoring, diagnostics, food quality, biomarkers, pharmaceuticals, and forensics. Comprised of twenty-five chapters divided into three sections exploring Fundamentals, Selected Applications, and Future Trends, the book covers such critical topics as: uncertainty in clinical chemistry measurements. Metal toxicology in clinical, forensic, and chemical pathology. Role of analytical chemistry in the safety of drug therapy. Atomic spectrometric techniques for the analysis of clinical samples. Biosensors for drug analysis. Use of X-ray techniques in medical research. Each chapter is written by one or more leading pioneers and experts in analytical chemistry. Contributions are based on a thorough review and analysis of the current literature as well as the authors' own firsthand experiences in the lab. References at the end of each chapter serve as a gateway to the literature, enabling readers to explore individual topics in greater depth. Presenting the latest achievements and challenges in the field, Analytical Techniques for Clinical Chemistry sets the foundation for future advances in laboratory research techniques. 

 Supplemental Images -- Exploring Fundamentals. Good Clinical Practice Principles: Legal Background and Applicability / Umberto Filibeck, Angela Del Vecchio, Fabrizio Galliccia -- Clinical Chemistry and the Quest for Quality / Sergio Caroli -- Uncertainty in Clinical Chemistry Measurements Including Preanalytical Variables / Marit Sverresdotter Sylte, Tore Wentzel-Larsen, Bj̜rn J Bolann -- The Role and Significance of Reference Values in the Identification and Evaluation of Trace Elements from Diet / Pietro Apostoli, Maria Cristina Ricossa -- Sample Collection, Storage, and Pretreatment in Clinical Chemistry / Andrew Taylor -- Metal Toxicology in Clinical, Forensic, and Chemical Pathology / Još A Centeno, Todor I Todorov, Gijsbert B van der Voet, Florabel G Mullick -- Selected Applications. Elemental Speciation in Clinical Sciences / Douglas M Templeton -- The Role of Analytical Chemistry in the Safety of Drug Therapy / Snd̀or G̲r̲g -- Analytical Techniques and Quality Control of Pharmaceuticals / Fedele Manna, Francesca Rossi, Rossella Fioravanti -- Detection of Drugs in Biological Fluids for Antidoping Control / Sabina Strano, Marcello Chiarotti -- The Applicability of Plasma-Based Techniques to Biological Monitoring / Ilse Steffan, Goran Vujicic -- Atomic Spectrometric Techniques for the Analysis of Clinical Samples / Pilar Bermejo Barrera, Antonio Moreda Pįeiro, Mar̕a del Carmen Barciela Alonso -- Applications of ICP-MS in Human Biomonitoring Studies / Peter Heitland, Helmut D K̲ster -- Molybdenum in Biological Samples and Clinical Significance of Serum Molybdenum / Munehiro Yoshida -- Application of Organometallic Speciation in Clinical Studies / Bin He, Chungang Yuan, Jing Sun, Guibin Jiang -- Biosensors for Drug Analysis / Daniela Deriu, Franco Mazzei -- Bioimaging of Metals and Proteomic Studies of Clinical Samples by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) / Sabine Becker, Susanne Becker -- Applications of LC-MS/MS in Clinical Laboratory Diagnostics / Uta Ceglarek, Georg Martin Fiedler, Joachim Thiery -- Metabolomics Using UPLC/HPLC-Tandem Mass Spectrometry in Diagnosis and Research of Inherited Metabolic Diseases / Willem Kulik, Andř B P van Kuilenburg -- Biomarkers of Oxidative Stress in Plasma and Urine / Papasani V Subbaiah -- The Use of X-Ray Techniques in Medical Research / Imre Szalk̤i, Gyula Zr̀ay, Norbert Szoboszlai -- Future Trends. A New Tool Based on the Use of Stable Isotopes and Isotope Pattern Deconvolution (IPD)-ICP-MS for Nutritional and Clinical Studies / Hčtor Gonzl̀ez Iglesias, Maria Luisa Ferǹndez-Snc̀hez, Alfredo Sanz-Medel -- Breath Analysis: Analytical Methodologies and Clinical Applications / Alessio Ceccarini, Fabio Di Francesco, Roger Fuoco, Silvia Ghimenti, Massimo Onor, Sara Tabucchi, Maria Giovanna Trivella -- Proteo-Metabolomic Strategies in the Future of Drug Development / Uwe Christians, Volker Schmitz, Jost Klawitter, Jelena Klawitter -- Basics in Laboratory Medicine: Past, Present, and Future / Lorǹd A Debreczeni, Anna Kovc̀say, Sandor Nagy.