Parasitic helminths : targets, screens, drugs and vaccines /

• Άλλοι συγγραφείς: Caffrey, Conor R.
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Weinheim, Germany : Wiley-VCH, 2012.
• Σειρά: Drug discovery in infectious diseases ; v. 3.
• Θέματα: Helminths.; Parasites.; Parasitic diseases > Treatment.; Parasitic diseases > Diagnosis.; Electronic books.

 Part one: targets -- Ligand-gated ion channels as targets for anthelmintic drugs: past, current, and future perspectives -- How relevant is Caenorhabditis elegans as a model for the analysis of parasitic nematode biology? -- Integrating and mining helminth genomes to discover and prioritize novel therapeutic targets -- Recent progress in transcriptomics of key gastrointestinal nematodes of animals: fundamental research toward new intervention strategies -- Harnessing genomic technologies to explore the molecular biology of liver flukes-major implications for fundamental and applied research -- RNA interference: a potential discovery tool for therapeutic targets of parasitic nematodes -- RNA interference as a tool for drug discovery in parasitic flatworms -- Part two: screens -- Mechanism-based screening strategies for anthelmintic discovery -- Identification and profiling of nematicidal compounds in veterinary parasitology -- Quantitative high-content screening-based drug discovery against helmintic diseases -- Use of rodent models in the discovery of novel anthelmintics -- To kill a mocking worm: strategies to improve Caenorhabditis elegans as a model system for use in anthelmintic discovery -- Part three: drugs -- Anthelmintic drugs: tools and shortcuts for the long road from discovery to product -- Antinematodal drugs: modes of action and resistance: and worms will not come to thee (Shakespeare: Cymbeline: iv, ii) -- Drugs and targets to perturb the symbiosis of Wolbachia and filarial nematodes -- Promise of Bacillus thuringiensis crystal proteins as anthelmintics -- Monepantel: from discovery to mode of action -- Discovery, mode of action, and commercialization of derquantel -- Praziquantel: too good to be replaced? -- Drug discovery for trematodiases: challenges and progress -- Part four: vaccines -- Barefoot thru' the valley of darkness: preclinical development of a human hookworm vaccine -- Vaccines linked to chemotherapy: a new approach to control helminth infections -- Antifilarial vaccine development: present and future approaches -- Proteases as vaccines against gastrointestinal nematode parasites of sheep and cattle -- Schistosomiasis vaccines: new approaches to antigen discovery and promising new candidates -- Sm14 Schistosoma mansoni fatty acid-binding protein: molecular basis for an antihelminth vaccine -- Mechanisms of immune modulation by Fasciola hepatica: importance for vaccine development and for novel immunotherapeutics -- Prospects for immunoprophylaxis against Fasciola hepatica (liver fluke) -- Vaccines against cestode parasites.