Drug repositioning : bringing new life to shelved assets and existing drugs /
BThe how's and why's of successful drug repositioning /b/ Drug repositioning, also known as drug reprofiling or repurposing, has become an increasingly important part of the drug development process. This book examines the business, technical, scientific, and operational challenges and opp...
| Άλλοι συγγραφείς: | , |
|---|---|
| Μορφή: | Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Hoboken, N.J. :
Wiley,
[2012]
|
| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Drug repositioning : the business case and current strategies to repurpose shelved candidates and marketed drugs / John Arrowsmith and Richard Harrison
- Opportunities and challenges associated with developing additional indications for clinical development candidates and marketed drugs / Donald E. Frail and Michael J. Barratt
- Clinical and operational considerations in repositioning marketed drugs and drug candidates / Damian O'Connell, David J. Sequeira, and Maria L. Miller
- Regulatory considerations and strategies for drug repositioning / Ken Phelps
- Computational and bioinformatic strategies for drug repositioning / Richard Mazzarella and Craig Webb
- Mining scientific and clinical databases to identify novel uses for existing drugs / Christos Andronis [and others]
- Predicting the polypharmacology of drugs : identifying new uses through chemoinformatics, structural informatics, and molecular modeling-based approaches / Li Xie [and others]
- Systematic phenotypic screening for novel synergistic combinations: a new paradigm for repositioning existing drugs / Margaret S. Lee
- Phenotypic in vivo screening to identify new, unpredicted indications for existing drugs and drug candidates / Michael S. Saporito, Christopher A. Lipinski, and Andrew G. Reaume
- Old drugs yield new discoveries : examples from the prodrug, chiral switch and site-selective deuteration strategies / Adam J. Morgan [and others]
- Repurposing drugs for tropical diseases : case studies and open-source screening initiatives / Curtis R. Chong
- Drug repositioning efforts by nonprofit foundations
- Business development strategies in the repositioning industry / Aris Persidis and Elizabeth T. Stark
- A case study in drug repositioning : Sosei / Akinori Mochizuki and Makiko Aoyama.
