Chemical biology : approaches to drug discovery and development to targeting disease /

• Άλλοι συγγραφείς: Civjan, Natanya (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, N.J. : Wiley, a John Wiley & Sons, Inc., Publication, [2012]
• Θέματα: Biochemistry.; Drug Discovery.; Drug Delivery Systems.; SCIENCE > Life Sciences > Biochemistry.; Electronic books.

"Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The sec...

Πίνακας περιεχομένων:

• Part I: Drug discovery and development. The role of chemical biology in drug discovery
• Computational approaches to drug discovery and development
• Design and selection of small molecule inhibitors
• Lead optimization in drug discovery
• Pharmacokinetics of drug candidates
• ADME properties of drugs
• Drug transport in living systems
• Blood-brain barrier: considerations in drug development and delivery
• Pharmacokinetic considerations: methods and systems of controlled drug delivery
• Pharmaceuticals: natural products and natural product models
• Part II: Chemical biology to understand and target disease. The role of chemical biology in understanding and treating disease: are small molecule "correctors" the way of the future?
• Anxiety disorders
• Chronic obstructive pulmonary disease (COPD)
• Depression
• Osteoarthritis
• Human immunodeficiency virus (HIV)
• Allergy and asthma
• Schizophrenia
• Protein misfolding and disease
• Protein trafficking diseases
• Metabolic diseases
• Mitochondrial medicine
• Lysosomal disorders.