Eukaryotic RNases and their partners in RNA degradation and biogenesis. Part A /

• Άλλοι συγγραφείς: Chanfreau, Guillaume, Tamanoi, Fuyuhiko
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: San Diego : Academic Press, 2012.
• Έκδοση: 1st ed.
• Σειρά: Enzymes ; v. 31.
• Θέματα: Enzymes.; Eukaryotic cells.; RNA.; SCIENCE > Life Sciences > Cell Biology.; Electronic books.

This special issue of The Enzymes is targeted towards researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This volume discusses Eukaryotic RNases and their partners in RNA degradation and biogenesis. Key features: * Contributions from leading authorities * Informs and...

Πίνακας περιεχομένων:

• Front Cover; Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis, Part A; Copyright; Contents; Preface; Chapter One: Biochemistry and Function of RNA Exosomes; 1. Introduction; 2. Cellular Functions of the Exosome; 2.1. Nuclear substrates; 2.2. RNA QC by the exosome; 2.3. mRNA turnover; 2.4. Regulation of chromatin activity by the exosome; 3. Composition of Exosomes and Their Related Complexes; 3.1. Ancestors of the eukaryotic exosome; 3.2. The eukaryotic exosome; 3.3. Enzymatic activities of the eukaryotic exosome; 3.3.1. The endo/exonuclease Dis3.
• 3.3.2. The exonuclease Rrp63.3.3. Activities of Exo10 and Exo11; 4. Exosome Cofactors; 4.1. Mtr4: A central helicase in nuclear RNA metabolism; 4.2. The Saccharomyces cerevisiae TRAMP complex and its human counterpart; 4.3. Rrp47p/C1D; 4.4. Mpp6; 4.5. Nrd1p and Nab3p; 4.6. The NEXT complex; 4.7. The SKI complex; 5. Concluding Remarks; Acknowledgments; References; Chapter Two: Plant Exosomes and Cofactors; 1. Introduction; 2. Composition of the Plant Exosome Core Complex; 2.1. Plant exosome subunits are often encoded by duplicated genes; 2.2. The exosome core complex of A. thaliana.
• 2.3. Arabidopsis CSL4 is dispensable for the stability of the core complex2.4. Functional specialization of exosome core subunits?; 2.4.1. Take home message 1; 3. Exosome-Related Activities and Cofactors in Plants; 3.1. Plants may have retained a catalytically active core complex; 3.2. Three RRP6-like proteins in different intracellular compartments; 3.3. The SKI complex is conserved in plants; 3.4. The Arabidopsis MTR4 homologue is a nucleolar protein; 3.4.1. Take home message 2; 4. Impact of Exosome-Mediated Degradation in Plants.
• 4.1. Polyadenylated substrates of the exosome have been identified4.2. A high level of redundancy among plant RNA degradation pathways; 5. Final Remarks; References; Chapter Three: Structure and Activities of the Eukaryotic RNA Exosome; 1. Introduction; 2. Global Architecture of the Eukaryotic Exosome Core; 3. RNase PH-Like Domains Comprise a PH-Like Ring in Eukaryotic Exosomes; 4. S1 and KH Domains Cap the PH-Like Ring; 5. Rrp44, a Hydrolytic Endoribonuclease and Processive Exoribonuclease; 6. Rrp44 and the 10-Component Exosome.
• 7. Rrp6, a Eukaryotic Exosome Subunit with Distributive Hydrolytic Activities8. Rrp44, Rrp6, and the 11-Component Nuclear Exosome; 9. Conclusions; Acknowledgments; References; Chapter Four: TRAMP Stimulation of Exosome; 1. TRAMP Is a Cofactor of Nuclear Exosome; 2. RNA Substrate Repertoire of TRAMP; 2.1. Quality control of ribosomes and the role of TRAMP on rDNA loci; 2.2. Surveillance of stable ncRNAs; 2.3. Turnover of unstable noncoding RNAs; 3. TRAMP Biochemistry and Structure; 3.1. Structure of the TRAMP complex; 3.2. RNA-binding properties of TRAMP subunits.