Enzyme technologies : pluripotent players in discovering therapeutic agents /

• Κύριος συγγραφέας: McCarthy, J. R.
• Άλλοι συγγραφείς: Yang, Hsiu-Chiung, Yeh, Wu-Kuang, 1942-
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, New Jersey : Wiley-Interscience, [2014]
• Σειρά: Chemical biology of enzymes for biotechnology and pharmaceutical applications ; v. 2.
• Θέματα: Enzyme inhibitors.; Enzymes > Pharmacokinetics.; Drugs > Design.; Enzymes > pharmacokinetics.; Drug Design.; SCIENCE > Biotechnology.; Electronic books.

"This book highlights how, what, and where enzymes have become critical in pharmaceutical and biotechnology research. It provides in-depth reviews of recent developments in select topics on biosynthesis, biocatalysis, and chemical biology of enzymes. Broad coverage of enzymatic assays includes...

Πίνακας περιεχομένων:

• Machine generated contents note: pt. A ENZYMES
• ESSENTIAL WORKHORSES IN PHARMACEUTICAL RESEARCH
• 1. Assay Technologies for Proteases / Rathnam Chaguturu
• 2. Discovery and Development of Isozyme-Selective Inhibitors Involved in Lipid Metabolism / Hiroshi Tomoda
• 3. Covalent Enzyme Inhibition in Drug Discovery and Development / Shujaath Mehdi
• 4. Preclinomics: Enzyme Assays and Rodent Models for Metabolic diseases / Richard G. Peterson
• pt. B ENZYMES
• INDISPENSABLE TOOLS FOR IMPROVING DRUGGABILITY
• 5. Enzymes and Targeted Activation of Prodrugs / Longqin Hu
• 6. Evolution of an Orally Active Prodrug of Gemcitabine / James R. McCarthy
• 7. Enzymatically Activated Phosphate and Phosphonate Prodrugs / Charles E. McKenna
• pt. C ENZYMES
• POWERFUL WEAPONS FOR CORRECTING NATURE'S ERRORS
• 8. Treatment Options for Mucopolysaccharidosis Type II (Hunter's Syndrome) / Michael Beck
• 9. Enzyme Replacement Therapy for Fabry Disease / Ozlem Goker-Alpan
• 10. Methods and Principles of Pancreatic Function Tests / Peter Layer.