More dead ends and detours : en route to successful total synthesis /

• Main Authors: Sierra, Miguel A. (Miguel Angel) (Author), Torre, María C. de la (Author), Cossío, Fernando P. (Author)
• Format: eBook
• Language: English
• Published: Weinheim, Germany : Wiley-VCH Verlag GmbH & Co. KGaA, 2013.
• Edition: First edition.
• Subjects: Organic compounds > Synthesis.; SCIENCE > Chemistry > Organic.; Electronic books.

Success comes in many forms and in synthesis it can be a failure that results in their ultimate successful solutions. This long-awaited sequel to "Dead Ends and Detours" retains the proven concept while featuring over 20 new case studies of failed strategies and their (successful) solution...

Table of Contents:

• The Inertia of Conventional Functional Groups
• The Diels-Alder Reaction
• The Aldol Condensation
• Cyclizations: Concerted, Radical, or Polar?
• Macrocycles: From Reluctant Ring Closure to Reluctant Ring Opening
• Stereochemistry, Controlled or Uncontrolled?
• Transition Metal-Mediated Transformations vs "Conventional" Reactions
• When Metathesis Fails
• Oxidations in C-C Bond Building
• The Failure of Epoxide Ring Opening and the Limits of Cascade Reactions.