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ocn854760495 |
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OCoLC |
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20180501122012.0 |
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m o d |
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cr cnu---unuuu |
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130731s2013 ne o 000 0 eng d |
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|a N$T
|b eng
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|d OPELS
|d CDX
|d OCLCQ
|d OCLCF
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|d OCLCO
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|d EBLCP
|d UKDOC
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|a 854977087
|a 857070035
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|a 9780124078017
|q (electronic bk.)
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|a 012407801X
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|a 9780124076754
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|a 0124076750
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|a (OCoLC)854760495
|z (OCoLC)854977087
|z (OCoLC)857070035
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|a QH430
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|a SCI
|x 029000
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|a 576.5
|2 23
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|a TEFA
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|a Advances in genetics.
|n Volume 83 /
|c edited by Theodore Friedmann, Jay Dunlap, Stephen Goodwin.
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| 264 |
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|a Amsterdam :
|b Academic Press,
|c 2013.
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| 300 |
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|a 1 online resource
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|a text
|b txt
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|a online resource
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|a The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. * Includes methods for testing with ethical, legal, and social implications * Critically analyzes future.
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|a Print version record.
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|a Front Cover; Advances in Genetics; Copyright; Contents; Contributors; Chapter One: Biology and Mechanisms of Short RNAs in Caenorhabditis elegans; 1. Introduction; 2. miRNA Function; 2.1. Biological effects of miRNAs; 2.1.1. Developmental timing; 2.1.2. Embryonic development; 2.1.3. Postembryonic development; 2.1.4. Physiology; 2.1.5. Longevity and stress response; 2.2. Biogenesis and molecular mechanisms of miRNAs; 3. RNAi and Endogenous siRNAs; 3.1. Exogenous RNAi pathway; 3.1.1. RDE-4 and Dicer; 3.1.2. RDE-1 Argonaute protein; 3.1.3. siRNA amplification and additional Argonautes.
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|a 3.1.4. Mutator proteins3.1.5. ABC transporters; 3.1.6. RDE-10/RDE-11 complex; 3.1.7. Transcriptional silencing induced by dsRNA; 3.1.8. Inheritance of dsRNA-induced gene silencing; 3.1.9. Chromatin modulators of the RNAi response; 3.2. Genomic and molecular features of endogenous RNAi; 3.2.1. Discovery of endo-siRNAs; 3.2.2. Distinction between WAGO- and CSR-1-associated 22G-endo-siRNAs; 3.2.3. 26G- and 22G-endo-siRNAs of the ERI pathway; 3.2.4. Competition between ADARs and endogenous RNAi; 3.3. Biological functions of RNAi; 3.3.1. Antiviral defense.
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|a 3.3.2. Silencing of transposons and repetitive elements3.3.3. A summary of the global effects of 22G-RNAs on the expression of endogenous genes; 3.3.4. Endogenous RNAi and adaptation to environment; 3.3.5. Developmental roles of the CSR-1 22G-RNA pathway; 3.3.6. Cooperation between RNAi and Rb; 3.3.7. The role of ALG-3/4 endo-siRNAs in sperm development; 4. 21U-RNAs, C. elegans piRNAs; 4.1. Biogenesis of 21U-RNAs; 4.2. Biological functions of 21U-RNAs; 4.2.1. Function in fertility; 4.2.2. Connection between 21U-RNAs, 22G-RNA production, and stable silencing of foreign DNA.
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|a 5. Systemic Features of RNAi5.1. dsRNA import channel SID-1 and the features of mobile RNA species; 5.2. Additional factors required for systemic and environmental RNAi; 5.2.1. SID-2; 5.2.2. SID-3; 5.2.3. SID-5; 6. Outlook; Acknowledgments; References; Chapter Two: Genetics of Immune Recognition and Response in Drosophila host defense; 1. Introduction; 1.1. Overview of Drosophila immune responses; 2. Toll Signaling in Drosophila; 2.1. Activation; 2.1.1. The Necrotic-Persephone axis; 2.1.2. PGRPs and GNBPs; 2.1.3. Mechanism of sensing bacterial and fungal cell wall components.
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|a 2.1.4. Ligand activation: The role of Spz2.2. Intracellular signaling; 2.3. Host-pathogen interaction upstream of Toll; 3. The Immune Deficiency Pathway; 3.1. Recognition and intracellular signaling; 3.2. Gut immunity and IMD signaling; 3.3. Host-pathogen interaction; 4. Immunity as a Sensor of Metabolism; 5. Concluding Remarks-Future Directions; Acknowledgments; References; Chapter Three: Recent Advances in Septum Biogenesis in Neurospora crassa; 1. Introduction; 2. Septum Ontogeny; 2.1. Septation during hyphal development; 2.2. Septation establishment: Regulators and positional markers.
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|a Genetics.
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7 |
|a SCIENCE
|x Life Sciences
|x Genetics & Genomics.
|2 bisacsh
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| 650 |
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|a Genetics.
|2 fast
|0 (OCoLC)fst00940117
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| 655 |
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|a Electronic books.
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| 700 |
1 |
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|a Friedmann, Theodore,
|d 1935-
|e editor.
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| 700 |
1 |
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|a Dunlap, Jay C.,
|e editor.
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| 700 |
1 |
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|a Goodwin, Stephen F.,
|e editor.
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| 776 |
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8 |
|i Print version:
|t Advances in genetics. Volume 83
|z 9780124076754
|w (OCoLC)853505664
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| 856 |
4 |
0 |
|u https://www.sciencedirect.com/science/bookseries/00652660/83
|z Full Text via HEAL-Link
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