Antibiotics : targets, mechanisms and resistance /

Λεπτομέρειες βιβλιογραφικής εγγραφής
Άλλοι συγγραφείς: Gualerzi, Claudio O., 1942-
Μορφή: Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Weinheim, Germany : Wiley-VCH, [2014]
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
Πίνακας περιεχομένων:
  • A chemist's survey of different antibiotic classes
  • Antibacterial discovery: problems and possibilities
  • Impact of microbial natural products on antibacterial drug discovery
  • Antibiotics and resistance: a fatal attraction
  • Fitness costs of antibiotic resistance
  • Inhibitors of cell-wall synthesis
  • Inhibitors of bacetrial cell partitioning
  • The membrane as a novel target site for antibiotics to kill persisting bacterial pathogens
  • Bacterial membrane, a key for controlling drug influx and efflux
  • Interference with bacterial cell-to-cell chemical signaling in development of new anti-infectives
  • Recent developments in inhibitors of bacterial type IIA topoisomerases
  • Antibiotics targeting bacterial RNA polymerase
  • Inhibitors targeting riboswitches and ribozymes
  • Targeting ribonuclease P
  • Involvement of ribosome biogenesis in antibiotic functions, acquired resistance, and future opportunities in drug discovery
  • Aminoacyl-tRNA synthetase inhibitors
  • Antibiotics targeting translation initiation in prokaryotes
  • Inhibitors of bacterial elongation factor EF-Tu
  • Aminoglycoside antibiotics: structural decoding of inhibitors targeting the ribosomal decoding A site
  • Reptidyltransferase inhibitors of the bacterial ribosome
  • Antibiotics inhibiting the translocation step of protein elongation on the ribosome
  • Antibiotics at the ribosomal exit tunnel
  • selected structual aspects
  • Targeting HSP70 to fight cancer and bad bugs: one and the same battle?