Cyclic-nucleotide phosphodiesterases in the central nervous system : from biology to drug discovery /

• Άλλοι συγγραφείς: Brandon, Nicholas J. (Επιμελητής έκδοσης), West, Anthony R., 1970- (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]
• Σειρά: Wiley series in drug discovery and development.
• Θέματα: Cyclic nucleotide phosphodiesterases.; Central nervous system > Physiology.; Nucleotides, Cyclic.; 3',5'-Cyclic-AMP Phosphodiesterases > metabolism.; 3',5'-Cyclic-AMP Phosphodiesterases > therapeutic use.; Central Nervous System > physiology.; Central Nervous System Diseases > drug therapy.; Drug Discovery.; MEDICAL > Physiology.; SCIENCE > Life Sciences > Human Anatomy & Physiology.; Central nervous system.; Electronic books.

Πίνακας περιεχομένων:

• Phosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter
• Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly
• Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin
• Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup
• Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella
• Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang
• Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell
• Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa
• Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P.P. Bollen, Kris Rutten, Olga A.H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts
• Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon
• Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West
• The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick
• Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin.