A handbook for DNA-encoded chemistry : theory and applications for exploring chemical space and drug discovery /

• Format: eBook
• Language: English
• Published: Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]
• Subjects: Combinatorial chemistry > Technique.; DNA > Synthesis.; MEDICAL > Pharmacology.; Combinatorial Chemistry Techniques > methods.; Drug Discovery > methods.; Gene Library.; Small Molecule Libraries > chemical synthesis.; Electronic books.
• Physical Description: 1 online resource.
• Bibliography: Includes bibliographical references and index.
• ISBN: 9781118832677 (epub); 1118832671 (epub); 9781118832691 (pdf); 1118832698 (pdf); 9781118832639 ( mobi); 1118832639 ( mobi); 9781118832738; 1118832736; 1118487680; 9781118487686
• DOI: 10.1002/9781118832738

This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combi.