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04394nam a2200721 4500 |
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ocn863127741 |
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OCoLC |
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20170124071855.5 |
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131115s2014 nju ob 001 0 eng |
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|a 2013046115
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|a DLC
|b eng
|e rda
|c DLC
|d YDX
|d EBLCP
|d MHW
|d N$T
|d IDEBK
|d E7B
|d YDXCP
|d DG1
|d CDX
|d STF
|d OCLCO
|d CHVBK
|d COO
|d RECBK
|d DEBBG
|d LOA
|d GrThAP
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|a 959876764
|a 960200866
|a 961614932
|a 962666289
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|a 9781118832677 (epub)
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|a 1118832671 (epub)
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|a 9781118832691 (pdf)
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|a 1118832698 (pdf)
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|a 9781118832639 ( mobi)
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|a 1118832639 ( mobi)
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|z 9781118487686 (cloth)
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|a 9781118832738
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|a 1118832736
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|a 1118487680
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|a 9781118487686
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|a AU@
|b 000052230774
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|a CHBIS
|b 010259680
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|a DEBBG
|b BV043396343
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|a (OCoLC)863127741
|z (OCoLC)959876764
|z (OCoLC)960200866
|z (OCoLC)961614932
|z (OCoLC)962666289
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|a pcc
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|a RS420
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|a QV 744
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|a MED
|x 071000
|2 bisacsh
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|a 615.1/9
|2 23
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|a MAIN
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|a A handbook for DNA-encoded chemistry :
|b theory and applications for exploring chemical space and drug discovery /
|c edited by Robert A. Goodnow, Jr.
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|a Hoboken, New Jersey :
|b John Wiley & Sons, Inc.,
|c [2014]
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300 |
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|a 1 online resource.
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336 |
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|a text
|2 rdacontent
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|a computer
|2 rdamedia
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|a online resource
|2 rdacarrier
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|a Includes bibliographical references and index.
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|a Just enough knowledge? -- A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry -- A history of DNA-encoding -- DNA-compatible chemistry -- Foundations of a DNA-encoded library (DEL) -- Practices for synthesizing DNA-encoded libraries -- Chemical gene design for DNA-encoded libraries -- Analytical challenges for DNA-encoded library systems -- Information technology: functionality and architectures for DNA-encoding -- Theoretical considerations of the application of DNA-encoded libraries to drug discovery -- Begin with the end in mind : the hit-to-lead process -- Enumeration and visualization of large combinatorial chemical libraries -- Screening large compound collections -- Reported applications of DNA-encoded library chemistry -- Dual-pharmacophore DNA-encoded chemical libraries -- Hit identification and hit follow-up -- Using DNA to program chemical synthesis, discover new reactions, and detect ligand binding -- An outlook and the changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches -- Keeping the promise? an outlook on dna chemical library technology.
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|a Description based on print version record and CIP data provided by publisher.
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|a This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combi.
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650 |
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|a Combinatorial chemistry
|x Technique.
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650 |
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|a DNA
|x Synthesis.
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650 |
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|a MEDICAL
|x Pharmacology.
|2 bisacsh
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650 |
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2 |
|a Combinatorial Chemistry Techniques
|x methods.
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650 |
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2 |
|a Drug Discovery
|x methods.
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650 |
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2 |
|a Gene Library.
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650 |
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2 |
|a Small Molecule Libraries
|x chemical synthesis.
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655 |
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4 |
|a Electronic books.
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655 |
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|a Electronic books.
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700 |
1 |
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|a Goodnow, Robert A.,
|c Jr.,
|e editor of compilation.
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776 |
0 |
8 |
|i Print version:
|t Handbook for DNA-encoded chemistry
|d Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]
|z 9781118487686
|w (DLC) 2013042727
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856 |
4 |
0 |
|u https://doi.org/10.1002/9781118832738
|z Full Text via HEAL-Link
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994 |
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|a 92
|b DG1
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