A handbook for DNA-encoded chemistry : theory and applications for exploring chemical space and drug discovery /

• Format: eBook
• Language: English
• Published: Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]
• Subjects: Combinatorial chemistry > Technique.; DNA > Synthesis.; MEDICAL > Pharmacology.; Combinatorial Chemistry Techniques > methods.; Drug Discovery > methods.; Gene Library.; Small Molecule Libraries > chemical synthesis.; Electronic books.

This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, str...

Table of Contents:

• Just enough knowledge?
• A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry
• A history of DNA-encoding
• DNA-compatible chemistry
• Foundations of a DNA-encoded library (DEL)
• Practices for synthesizing DNA-encoded libraries
• Chemical gene design for DNA-encoded libraries
• Analytical challenges for DNA-encoded library systems
• Information technology: functionality and architectures for DNA-encoding
• Theoretical considerations of the application of DNA-encoded libraries to drug discovery
• Begin with the end in mind : the hit-to-lead process
• Enumeration and visualization of large combinatorial chemical libraries
• Screening large compound collections
• Reported applications of DNA-encoded library chemistry
• Dual-pharmacophore DNA-encoded chemical libraries
• Hit identification and hit follow-up
• Using DNA to program chemical synthesis, discover new reactions, and detect ligand binding
• An outlook and the changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches
• Keeping the promise? an outlook on dna chemical library technology.