Peptidomimetics in organic and medicinal chemistry /

• Κύριοι συγγραφείς: Trabocchi, Andrea (Συγγραφέας), Guarna, Antonio (Συγγραφέας)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Chichester, West Sussex, UK ; Hoboken, NJ : John Wiley & Sons Inc., 2014.
• Θέματα: Peptide drugs.; Proteins > Therapeutic use.; Drugs > Design.; SCIENCE / Chemistry / Physical & Theoretical.; Electronic books.
• Φυσική περιγραφή: 1 online resource.
• Βιβλιογραφία: Includes bibliographical references and index.
• ISBN: 9781118683149 (ePub); 1118683145 (ePub); 9781118683842 (Adobe PDF); 1118683846 (Adobe PDF); 9781118683033; 111868303X; 1119950600; 9781119950608; 9781306546980; 1306546982
• DOI: 10.1002/9781118683033

"A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"--
"Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"--