Peptidomimetics in organic and medicinal chemistry /

• Κύριοι συγγραφείς: Trabocchi, Andrea (Συγγραφέας), Guarna, Antonio (Συγγραφέας)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Chichester, West Sussex, UK ; Hoboken, NJ : John Wiley & Sons Inc., 2014.
• Θέματα: Peptide drugs.; Proteins > Therapeutic use.; Drugs > Design.; SCIENCE / Chemistry / Physical & Theoretical.; Electronic books.

 "A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"--   Provided by publisher. 

 Title Page; Copyright; Dedication; Preface; Abbreviations; Part I: The Basics of Peptidomimetics; Chapter 1: The Basics of Peptidomimetics; 1.1 Introduction; 1.2 Definition and Classification; 1.3 Strategic Approaches to Peptidomimetic Design; 1.4 Successful Examples of Peptidomimetic Drugs; 1.5 Conclusion; References; Chapter 2: Synthetic Approaches towards Peptidomimetic Design; 2.1 Introduction; 2.2 Local Modifications; 2.3 Global Restrictions through Cyclic Peptidomimetics; 2.4 Peptidomimetic Scaffolds; 2.5 Conclusions; References; Part II: Synthetic Methods and Molecules