Peptidomimetics in organic and medicinal chemistry /
"A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.Peptidomimet...
| Κύριοι συγγραφείς: | , |
|---|---|
| Μορφή: | Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Chichester, West Sussex, UK ; Hoboken, NJ :
John Wiley & Sons Inc.,
2014.
|
| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Title Page; Copyright; Dedication; Preface; Abbreviations; Part I: The Basics of Peptidomimetics; Chapter 1: The Basics of Peptidomimetics; 1.1 Introduction; 1.2 Definition and Classification; 1.3 Strategic Approaches to Peptidomimetic Design; 1.4 Successful Examples of Peptidomimetic Drugs; 1.5 Conclusion; References; Chapter 2: Synthetic Approaches towards Peptidomimetic Design; 2.1 Introduction; 2.2 Local Modifications; 2.3 Global Restrictions through Cyclic Peptidomimetics; 2.4 Peptidomimetic Scaffolds; 2.5 Conclusions; References; Part II: Synthetic Methods and Molecules
- Chapter 3: Peptidomimetic Bioisosteres3.1 Introduction; 3.2 Peptide Bond Isosteres; 3.3 Side-Chain Isosteres; 3.4 Dipeptide Isosteres; 3.5 Tripeptide Isosteres; 3.6 Conclusion; References; Chapter 4: Solid-Phase Synthesis and Combinatorial Approaches to Peptidomimetics; 4.1 Introduction; 4.2 Solid-Phase Synthesis of Peptidomimetics; 4.3 Conclusion; References; Chapter 5: Click Chemistry: The Triazole Ring as a Privileged Peptidomimetic Scaffold; 5.1 Introduction; 5.2 Triazole-Containing Peptidomimetics Elaborated through 'Click Chemistry'; 5.3 Relevant Applications in Drug Discovery
