Advances in carbohydrate chemistry and biochemistry. Volume 69 /

• Άλλοι συγγραφείς: Horton, Derek, 1932- (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Amsterdam : Academic Press, 2013.
• Θέματα: Carbohydrates > Periodicals.; SCIENCE > Chemistry > Organic.; Carbohydrates.; Electronic books.; Periodicals.

Since its inception in 1945, this serial has provided critical and informative articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles pro...

Πίνακας περιεχομένων:

• Front Cover; Advances in Carbohydrate Chemistry and Biochemistry; Copyright; Contents; Contributors; Preface; Obituaries 1: Stephen John Charles Angyal; The Andrews Lectures; Administration; Acknowledgments; List of Publications by S.J. Angyal; A. Inositols and Sugars; B. Other Papers; Obituaries 2: John Grant Buchanan; List of Publications by J. Grant Buchanan; Obituaries 3: Saul Roseman; Biosynthesis and Metabolism of Simple Sugars; Biosynthesis of Mucin Glycoproteins and Brain Gangliosides; Discovery of the Sialyltransferase Catalyzing the In Vitro Biosynthesis of Sialyl-Lactose.
• Biosynthesis of Oligoglycosyl-Glycoproteins Studied at the Johns Hopkins University (1965-1970)Bacterial Phosphotransferase System (PTS) Studied at the Johns Hopkins University (1965-1985); Intercellular Adhesion and the ``Fish Theory ́ ́ from the Johns Hopkins University (1966-1972); Degradation of Chitin and Hexosamine Metabolism in the Sea World (1985-2011); Acknowledgments; References; Obituaries 4: De novo asymmetric synthesis of the pyranoses: From monosaccharides to oligosaccharides; I. Introduction; 1. Background; II. Masamune-Sharpless Approach to the Hexoses.
• III. Danishefsky Hetereo-Diels-Alder Approach to Various PyranosesIV. MacMillan Iterative Aldol Approach to Various Pyranoses; V. Asymmetric Oxidative Biocatalytic Aldol Approach to Various Pyranoses; VI. Sharpless Dihydroxylation/Enzymatic Aldol Approach 2-Ketoses; VII. Non-De Novo Asymmetric Approaches to Pyranoses; 1. Dondoni Thiazole Approach; 2. Seeberger Approaches; 3. Reissig Approaches; VIII. O'Doherty De Novo Approach to Pyranoses; 1. De Novo Use of the Achmatowicz Approach to Pyranoses; 2. Iterative Dihydroxylation of Dienoates; 3. Palladium-Catalyzed Glycosylation.
• 4. Applications to Synthesis and Medicinal ChemistryAcknowledgments; References; Obituaries 5: Recent advances toward the development of inhibitors to attenuate tumor metastasis via the interruption of lectin-ligand i ... ; I. Introduction; 1. Siglecs; 2. Galectins; 3. Selectins; II. Roles of Carbohydrates in Tumor Development; 1. Abnormal Glycosylation in Tumors; 2. Abnormal Glycosylation and Cancer Metastasis; III. Roles of Lectins in Tumor Development; 1. Siglecs; 2. Galectins; 3. Selectins; IV. Developing Anticancer Approaches by Targeting Tumor-Associated Carbohydrate-Lectin Systems.
• 1. Efforts Toward Galectin Inhibitorsa. Inhibition of Galectin Expression; b. Anti-Galectin mAbs or Soluble Recombinant Galectins; c. Inhibition of Biosynthesis of Tumor-Associated Carbohydrate Antigens; d. Modified Citrus Pectin (MCP) and Other Dietary Polysaccharides; e. Small Carbohydrate-Based Inhibitors for Galectins; (i). 3-O-Aromatization; (ii). 2-O-Aromatization; (iii). C-1-Aromatization; (iv). C-2-Epimerization; (v). Anomeric Oximes; (vi). C-2 and C-4 Double Epimerizations; (vii). Anionic Inhibitors; (viii). C-Galactosyl Compounds; (ix). 1-Thiogalactosides; f. Multivalent Inhibitors.