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05767nam a2200757 4500 |
| 001 |
ocn869847755 |
| 003 |
OCoLC |
| 005 |
20170124071410.4 |
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m o d |
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cr ||||||||||| |
| 008 |
140127s2014 iau ob 001 0 eng |
| 010 |
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|a 2014003283
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|a DLC
|b eng
|e rda
|c DLC
|d YDX
|d N$T
|d YDXCP
|d E7B
|d CUS
|d DG1
|d OCLCF
|d CDX
|d RECBK
|d COO
|d EBLCP
|d DEBBG
|d GrThAP
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| 019 |
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|a 927509063
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|a 9781118847015 (ePub)
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|a 1118847016 (ePub)
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|a 9781118846940 (Adobe PDF)
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|a 111884694X (Adobe PDF)
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|z 9781118125656 (hardback)
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|a 9781118847237 (electronic bk.)
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|a 1118847237 (electronic bk.)
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|a 1118125657
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|a 9781118125656
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1 |
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|a NZ1
|b 15581391
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|a CHVBK
|b 325939896
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1 |
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|a CHBIS
|b 010259650
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| 029 |
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|a NZ1
|b 15906859
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|a GBVCP
|b 821064541
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|a AU@
|b 000058366570
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| 029 |
1 |
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|a DEBBG
|b BV043396525
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| 035 |
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|a (OCoLC)869847755
|z (OCoLC)927509063
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| 042 |
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|a pcc
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| 050 |
0 |
0 |
|a QP551
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| 072 |
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7 |
|a SCI
|x 056000
|2 bisacsh
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| 082 |
0 |
0 |
|a 571.6/58
|2 23
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| 084 |
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|a SCI017000
|2 bisacsh
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| 049 |
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|a MAIN
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| 245 |
0 |
0 |
|a Ribosome-inactivating proteins :
|b biology and applications /
|c edited by Fiorenzo Stirpe, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, Bologna, Italy, Douglas A. Lappi, Advanced Targeting Systems, Inc., San Diego, California, USA.
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| 264 |
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1 |
|a Ames, Iowa :
|b Wiley,
|c 2014.
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| 300 |
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|a 1 online resource.
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| 336 |
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|a text
|2 rdacontent
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| 337 |
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|a computer
|2 rdamedia
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| 338 |
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|a online resource
|2 rdacarrier
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| 520 |
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|a "This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain"--
|c Provided by publisher.
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| 520 |
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|a "Ribosome-inactivating Proteins is a reference book which will provide up-to-date information on all aspects of ribosome-inactivating proteins (RIPs)"--
|c Provided by publisher.
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| 504 |
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|a Includes bibliographical references and index.
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| 588 |
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|a Description based on print version record and CIP data provided by publisher.
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| 505 |
0 |
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|a ""Title page -- Copyright page -- Contributors -- Preface -- 1 Introduction and History -- Introduction -- Identification and Distribution in Nature -- Mechanism of Action -- Effects on Cells and Animals -- Role in Nature -- Practical Applications -- Bioweapons -- Future Challenges -- References -- 2 Occurrence and Taxonomical Distribution of Ribosome-inactivating Proteins Belonging to the Ricin/Shiga Toxin Superfamily -- Introduction -- How to Investigate the Distribution of Proteins with an N-glycosidase Domain? -- Conclusions -- Acknowledgments""
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| 505 |
8 |
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|a ""Introduction -- Family Sambuceae -- Type 2 RIPs from Other families -- Uses of nontoxic type 2 RIPs -- Concluding remarks -- Acknowledgment -- References -- 6 The Intracellular Journey of Type 2 Ribosome-inactivating Proteins -- Introduction -- Cell Surface Events -- Endosome to TGN Sorting -- From the Golgi to the ER -- Reductive Separation and Destabilization of the Holotoxin Subunits -- Dislocation Across the ER Membrane -- Cytosolic Post-dislocation Events that Restore Catalytic Activity -- Concluding Remarks -- Acknowledgements -- References""
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| 505 |
8 |
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|a ""7 Shiga Toxins -- Introduction -- Purification of Shiga Toxins -- Structure and Mechanism of Action of Shiga Toxins -- Role of Shiga Toxins in the Pathogenesis of HUS -- The 2011 German STEC Outbreak -- References -- 8 The Structure and Action of Ribosome-inactivating Proteins -- Introduction -- Acknowledgments -- References -- 9 Updated Model of the Molecular Evolution of RIP Genes -- Introduction -- Important Issues to be Considered in View of the Evolution of RIP Genes""
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| 505 |
8 |
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|a ""Dissecting RIP Genes and RIP Gene Families by in silico Analysis of Genome and Transcriptome Data -- New Insights in the Overall Phylogeny of Plant RIPs -- An Updated Model of the Molecular Evolution of the Plant RIP Gene Family -- What is the Evolutionary Link Between Plant and Non-Plant RIPs? -- Conclusions -- References -- 10 Enzymology of the Ribosome-inactivating Proteins -- Introduction -- Ricin as RNA N-glycosidase -- Role of SRL in Ribosomes -- Ribosomal RNA Apurinic Site-specific Lyase â€" Intrinsic Stability of the Ribosomes -- Action of RIPs on DNA""
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| 650 |
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0 |
|a Proteins
|x Synthesis.
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| 650 |
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0 |
|a Ribosomes
|x Structure.
|
| 650 |
|
7 |
|a SCIENCE / Life Sciences / Cytology.
|2 bisacsh
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| 650 |
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2 |
|a Protein Biosynthesis.
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| 650 |
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2 |
|a Ribosomes.
|
| 650 |
|
7 |
|a Proteins
|x Synthesis.
|2 fast
|0 (OCoLC)fst01079764
|
| 650 |
|
7 |
|a Ribosomes
|x Structure.
|2 fast
|0 (OCoLC)fst01097321
|
| 650 |
|
4 |
|a SCIENCE
|x Life Sciences
|x Cytology.
|
| 655 |
|
4 |
|a Electronic books.
|
| 655 |
|
0 |
|a Electronic books.
|
| 700 |
1 |
|
|a Stirpe, Fiorenzo,
|e editor of compilation.
|
| 700 |
1 |
|
|a Lappi, Douglas A.,
|e editor of compilation.
|
| 776 |
0 |
8 |
|i Print version:
|t Ribosome-inactivating proteins
|d Ames, Iowa : John Wiley & Sons Inc., 2014
|z 9781118125656
|w (DLC) 2014002677
|
| 856 |
4 |
0 |
|u https://doi.org/10.1002/9781118847237
|z Full Text via HEAL-Link
|
| 994 |
|
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|a 92
|b DG1
|
