Ribosome-inactivating proteins : biology and applications /
"This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, includi...
| Μορφή: | Ηλ. βιβλίο |
|---|---|
| Γλώσσα: | English |
| Έκδοση: |
Ames, Iowa :
Wiley,
2014.
|
| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- ""Title page
- Copyright page
- Contributors
- Preface
- 1 Introduction and History
- Introduction
- Identification and Distribution in Nature
- Mechanism of Action
- Effects on Cells and Animals
- Role in Nature
- Practical Applications
- Bioweapons
- Future Challenges
- References
- 2 Occurrence and Taxonomical Distribution of Ribosome-inactivating Proteins Belonging to the Ricin/Shiga Toxin Superfamily
- Introduction
- How to Investigate the Distribution of Proteins with an N-glycosidase Domain?
- Conclusions
- Acknowledgments""
- ""Introduction
- Family Sambuceae
- Type 2 RIPs from Other families
- Uses of nontoxic type 2 RIPs
- Concluding remarks
- Acknowledgment
- References
- 6 The Intracellular Journey of Type 2 Ribosome-inactivating Proteins
- Introduction
- Cell Surface Events
- Endosome to TGN Sorting
- From the Golgi to the ER
- Reductive Separation and Destabilization of the Holotoxin Subunits
- Dislocation Across the ER Membrane
- Cytosolic Post-dislocation Events that Restore Catalytic Activity
- Concluding Remarks
- Acknowledgements
- References""
- ""7 Shiga Toxins
- Introduction
- Purification of Shiga Toxins
- Structure and Mechanism of Action of Shiga Toxins
- Role of Shiga Toxins in the Pathogenesis of HUS
- The 2011 German STEC Outbreak
- References
- 8 The Structure and Action of Ribosome-inactivating Proteins
- Introduction
- Acknowledgments
- References
- 9 Updated Model of the Molecular Evolution of RIP Genes
- Introduction
- Important Issues to be Considered in View of the Evolution of RIP Genes""
- ""Dissecting RIP Genes and RIP Gene Families by in silico Analysis of Genome and Transcriptome Data
- New Insights in the Overall Phylogeny of Plant RIPs
- An Updated Model of the Molecular Evolution of the Plant RIP Gene Family
- What is the Evolutionary Link Between Plant and Non-Plant RIPs?
- Conclusions
- References
- 10 Enzymology of the Ribosome-inactivating Proteins
- Introduction
- Ricin as RNA N-glycosidase
- Role of SRL in Ribosomes
- Ribosomal RNA Apurinic Site-specific Lyase â€" Intrinsic Stability of the Ribosomes
- Action of RIPs on DNA""
