Multiple sclerosis and CNS inflammatory disorders /

• Άλλοι συγγραφείς: Samkoff, Lawrence M., 1958- (Επιμελητής έκδοσης), Goodman, Andrew D., 1952- (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Chichester, West Sussex, UK : John Wiley & Sons Inc., 2014.
• Σειρά: Neurology in practice.
• Θέματα: Multiple Sclerosis.; Central Nervous System Diseases > immunology.; Neurogenic Inflammation > physiopathology.; Multiple sclerosis.; Central nervous system > Diseases > Immunological aspects.; HEALTH & FITNESS / Diseases / General; MEDICAL / Clinical Medicine; MEDICAL / Diseases; MEDICAL / Evidence-Based Medicine; MEDICAL / Internal Medicine; Neurogenic Inflammation - physiopathology.; Electronic books.

"Multiple Sclerosis and CNS Inflammatory Disorders is a practical guide to effective care of patients with multiple sclerosis and other neuroimmunologic disorders. It provides the scientific basis of multiple sclerosis, and its etiology, epidemiology and pathogenesis. It covers the diagnostic p...

Πίνακας περιεχομένων:

• ""Title page
• Copyright page
• Contributors
• Series Foreword
• Preface
• 1 Etiology
• Background
• Genes
• Gender effects: Genetic or biologic?
• The role of the environment
• Combining risk factors
• Conclusion
• Acknowledgment
• References
• 2 Immunopathogenesis of Multiple Sclerosis
• What does the neuropathology of MS tell us about its pathogenesis?
• Gray matter pathology
• Multiple sclerosis as an autoimmune disease
• Candidates for the self-antigen in multiple sclerosis
• Antigen spreading
• Epitope spreading""
• ""Outside-in versus inside-out?
• Lymphocyte trafficking into the CNS
• Role of T cells in MS
• Role of B cells and humoral immunity
• Role of microglia and macrophages
• Role of other cells: Dendritic cells and astrocytes
• Role of cytokines
• What might trigger autoimmunity?
• Further Reading
• 3 Diagnostic Process
• Introduction
• Clinical features of MS
• Diagnostic evaluation of MS
• Conclusion
• Further Reading
• 4 MRI in Diagnosis and Disease Monitoring
• Introduction
• MRI at presentation
• MRI diagnostic criteria""
• ""MRI consensus protocol
• MRI for monitoring disease and treatment
• Limitations
• Nonconventional MRI
• Conclusions
• Acknowledgments
• References
• 5 Relapsing MS: Disease Staging and Therapeutic Algorithms
• Introduction
• Window
• Prognostic factors
• Therapy
• Initiation
• Suboptimal response
• Combination therapy
• Rescue therapy
• Escalation
• Rapid advancement
• Conclusion
• Newer oral agents
• Further Reading
• 6 Progressive MS Treatment Algorithms
• Background
• Challenges to clinical trials in progressive MS""
• ""Clinical trials in progressive MS
• Monitoring progressive MS in clinical practice
• Treatment of progressive MS in clinical practice
• Stopping disease-modifying therapy
• Neuroprotective strategies
• Other treatment considerations
• Further Reading
• 7 Sex-Determined Issues in Multiple Sclerosis
• Epidemiology of MS and gender
• Basic science of sex hormone and chromosome differences seen in MS
• Reproductive issues in MS
• Pregnancy and the MS patient
• Breastfeeding
• Female cancers
• Male sex hormones and concerns for the male patient""
• ""Acknowledgments
• References
• 8 Pediatric Multiple Sclerosis
• Introduction
• Definitions
• Clinical outcome following a first demyelinating attack
• Epidemiology and risk factors
• Clinical presentation
• Disease course
• Diagnostic considerations
• Differential diagnosis
• Treatment of acute demyelinating attacks
• Disease-modifying therapy
• Escalation of care for severe MS
• Symptomatic therapy
• Cognitive dysfunction and quality of life considerations
• Conclusions and future directions
• Further Reading""