Drug transporters : molecular characterization and role in drug disposition /

• Άλλοι συγγραφείς: You, Guofeng (Επιμελητής έκδοσης), Morris, Marilyn Emily (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]
• Έκδοση: Second edition.
• Σειρά: Wiley series in drug discovery and development.
• Θέματα: Carrier proteins.; Drug carriers (Pharmacy); SCIENCE > Life Sciences > Anatomy & Physiology.; Pharmakokinetik; Arzneimittel; Chemische Synthese; Arzneimittelwechselwirkung; Biological Transport > physiology.; Membrane Transport Proteins > physiology.; Pharmacokinetics.; Electronic books.

 Overview of drug transporter families -- Organic Cation and Zwitterion transporters OCT, OCTN -- Organic anion transporters OAT -- Organic anion transporting polypeptides OATP -- Mammalian peptide transporters PEPT -- The monocarboxylate transporters MCT -- The nucleoside transporters CNT, ENT -- Bile acid transporters -- Multidrug resistance protein P-glycoprotein -- Multidrug resistance-associated proteins MRP -- Breast cancer resistance protein BCRP -- Multidrug and toxin extrusion proteins MATE -- Drug transport in the liver -- Drug transport in the brain -- Drug transport in the kidney -- Drug transport in the intestine -- Drug transport in the placenta -- Experimental approaches to studying drug transport -- Transporters in drug discovery in silico approaches -- Polymorphisms of drug transporters and clinical relevance -- Diet/nutrient interactions with drug transporters -- Clinical relevance drug-drug interactions, pharmacokinetics, pharmacodynamics and toxicity -- Regulatory science perspectives on transporter studies in drug development.