Drug transporters : molecular characterization and role in drug disposition /

• Άλλοι συγγραφείς: You, Guofeng (Επιμελητής έκδοσης), Morris, Marilyn Emily (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]
• Έκδοση: Second edition.
• Σειρά: Wiley series in drug discovery and development.
• Θέματα: Carrier proteins.; Drug carriers (Pharmacy); SCIENCE > Life Sciences > Anatomy & Physiology.; Pharmakokinetik; Arzneimittel; Chemische Synthese; Arzneimittelwechselwirkung; Biological Transport > physiology.; Membrane Transport Proteins > physiology.; Pharmacokinetics.; Electronic books.

Πίνακας περιεχομένων:

• Overview of drug transporter families
• Organic Cation and Zwitterion transporters OCT, OCTN
• Organic anion transporters OAT
• Organic anion transporting polypeptides OATP
• Mammalian peptide transporters PEPT
• The monocarboxylate transporters MCT
• The nucleoside transporters CNT, ENT
• Bile acid transporters
• Multidrug resistance protein P-glycoprotein
• Multidrug resistance-associated proteins MRP
• Breast cancer resistance protein BCRP
• Multidrug and toxin extrusion proteins MATE
• Drug transport in the liver
• Drug transport in the brain
• Drug transport in the kidney
• Drug transport in the intestine
• Drug transport in the placenta
• Experimental approaches to studying drug transport
• Transporters in drug discovery in silico approaches
• Polymorphisms of drug transporters and clinical relevance
• Diet/nutrient interactions with drug transporters
• Clinical relevance drug-drug interactions, pharmacokinetics, pharmacodynamics and toxicity
• Regulatory science perspectives on transporter studies in drug development.