Telomeres in health and disease /

Telomeres in health and disease /

This special volume of Progress in Molecular Biology and Translational Science focuses on telomeres in health and disease. This volume covers a variety of topics with reviews written by experts in the field. Contributions from specialists in telomere diseases Informs and updates on how telomere dysf...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Άλλοι συγγραφείς: Calado, Rodrigo
Μορφή: Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Burlington : Elsevier Science, 2014.
Σειρά:Progress in molecular biology and translational science ; v. 125.
Θέματα:
Telomerase.
SCIENCE > Life Sciences > Biochemistry.
Electronic books.
Διαθέσιμο Online:Full Text via HEAL-Link
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490 1 |a Progress in molecular biology and translational science ;  |v v. 125 
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505 0 |a Front Cover; Telomeres in Health and Disease; Copyright; Contents; Contributors; Preface; Chapter One: Telomere and Telomerase Biology; 1. Introduction; 2. The General Structure of Telomeric DNA; 2.1. Telomere loops and G-quartets: Specialized structures at the ends of eukaryotic chromosomes; 3. Replication of Telomeres; 3.1. The telomerase RNP complex; 3.1.1. The reverse transcriptase component; 3.1.2. Telomerase accessory factors; 3.1.3. The telomerase RNA component; 3.1.4. How telomeres are replicated by telomerase; 3.1.5. Regulation of telomerase activity in mammals. 
505 8 |a 3.2. Telomere replication in the absence of telomerase4. Telomeric Chromatin: Implications for End Protection, Telomere Replication, and Telomere Length Regulation; 4.1. CST: The major telomere end-binding complex on eukaryotic telomeres; 4.2. Shelterin: A conserved, double-stranded, telomeric protein complex that associates with the telomere end-binding CST ... ; 5. TERRA: The Telomeric RNA Transcript; 6. Consequences of Telomere Deprotection; Acknowledgments; References; Chapter Two: Human Telomeres and Telomere Biology Disorders; 1. Introduction; 2. Telomere Biology in Humans. 
505 8 |a 2.1. Telomeric structure2.2. Telomerase and telomere-associated proteins; 2.3. Alternative lengthening of telomeres; 2.4. Measuring TL; 3. What Is a TBD?; 4. Clinical Features of the TBDs; 4.1. Dyskeratosis congenita; 4.2. Hoyeraal-Hreidarsson syndrome; 4.3. Revesz syndrome; 4.4. Coats plus syndrome/CRMCC; 4.5. Aplastic anemia; 4.6. Pulmonary fibrosis; 4.7. Nonalcoholic/noninfectious liver disease; 4.8. Genetic anticipation; 5. Germ-Line Genetics of TBDs; 6. Diagnosing TBDs; 7. Genetic Counseling Considerations; 8. Clinical Management; 8.1. Bone marrow failure; 8.2. Pulmonary fibrosis. 
505 8 |a 9. Summary and Future DirectionsAcknowledgments; References; Chapter Three: Telomere Biology in Stem Cells and Reprogramming; 1. Introduction; 1.1. A variety of stem cells throughout organismal development; 1.2. Telomeres cap chromosomal ends; 2. Telomere Homeostasis in Stem Cells; 2.1. Telomerase activity in pluripotent stem cells; 2.2. Telomerase activity in adult multipotent cells; 2.2.1. Hematopoietic system; 2.2.2. Hair follicle stem cells; 2.2.3. Intestinal stem cells; 2.2.4. Muscle stem cells; 2.2.5. Neural stem cells; 2.2.6. Spermatogonial stem cells. 
505 8 |a 2.3. Organismal consequences of telomere attrition in stem cells2.4. Noncanonical roles of telomerase in stem cell regulation; 3. Cellular Reprogramming; 3.1. Somatic cell nuclear transfer and cell fusion; 3.1.1. Telomere biology in SCNT; 3.2. Reprogramming through induced pluripotency; 3.2.1. Telomere reprogramming in iPS cells; 3.2.2. Derivation of IPS cells harboring disease-associated telomerase mutations; 4. Conclusions; References; Chapter Four: Telomere Dynamics and Aging. 
500 |a 1. Introduction: Telomere Structure, Determinants of Telomere Dynamics, Measurement Parameters, and Regulation Mechanisms. 
520 |a This special volume of Progress in Molecular Biology and Translational Science focuses on telomeres in health and disease. This volume covers a variety of topics with reviews written by experts in the field. Contributions from specialists in telomere diseases Informs and updates on how telomere dysfunction may cause disease in humans. 
650 0 |a Telomerase. 
650 7 |a SCIENCE  |x Life Sciences  |x Biochemistry.  |2 bisacsh 
650 7 |a Telomerase.  |2 fast  |0 (OCoLC)fst01147182 
655 4 |a Electronic books. 
700 1 |a Calado, Rodrigo. 
776 0 8 |i Print version:  |a Calado, Rodrigo.  |t Telomeres in Health and Disease.  |d Burlington : Elsevier Science, ©2014  |z 9780123978981 
830 0 |a Progress in molecular biology and translational science ;  |v v. 125. 
856 4 0 |u https://www.sciencedirect.com/science/bookseries/18771173/125  |z Full Text via HEAL-Link 

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