Telomeres in health and disease /

• Άλλοι συγγραφείς: Calado, Rodrigo
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Burlington : Elsevier Science, 2014.
• Σειρά: Progress in molecular biology and translational science ; v. 125.
• Θέματα: Telomerase.; SCIENCE > Life Sciences > Biochemistry.; Electronic books.

This special volume of Progress in Molecular Biology and Translational Science focuses on telomeres in health and disease. This volume covers a variety of topics with reviews written by experts in the field. Contributions from specialists in telomere diseases Informs and updates on how telomere dysf...

Πίνακας περιεχομένων:

• Front Cover; Telomeres in Health and Disease; Copyright; Contents; Contributors; Preface; Chapter One: Telomere and Telomerase Biology; 1. Introduction; 2. The General Structure of Telomeric DNA; 2.1. Telomere loops and G-quartets: Specialized structures at the ends of eukaryotic chromosomes; 3. Replication of Telomeres; 3.1. The telomerase RNP complex; 3.1.1. The reverse transcriptase component; 3.1.2. Telomerase accessory factors; 3.1.3. The telomerase RNA component; 3.1.4. How telomeres are replicated by telomerase; 3.1.5. Regulation of telomerase activity in mammals.
• 3.2. Telomere replication in the absence of telomerase4. Telomeric Chromatin: Implications for End Protection, Telomere Replication, and Telomere Length Regulation; 4.1. CST: The major telomere end-binding complex on eukaryotic telomeres; 4.2. Shelterin: A conserved, double-stranded, telomeric protein complex that associates with the telomere end-binding CST ... ; 5. TERRA: The Telomeric RNA Transcript; 6. Consequences of Telomere Deprotection; Acknowledgments; References; Chapter Two: Human Telomeres and Telomere Biology Disorders; 1. Introduction; 2. Telomere Biology in Humans.
• 2.1. Telomeric structure2.2. Telomerase and telomere-associated proteins; 2.3. Alternative lengthening of telomeres; 2.4. Measuring TL; 3. What Is a TBD?; 4. Clinical Features of the TBDs; 4.1. Dyskeratosis congenita; 4.2. Hoyeraal-Hreidarsson syndrome; 4.3. Revesz syndrome; 4.4. Coats plus syndrome/CRMCC; 4.5. Aplastic anemia; 4.6. Pulmonary fibrosis; 4.7. Nonalcoholic/noninfectious liver disease; 4.8. Genetic anticipation; 5. Germ-Line Genetics of TBDs; 6. Diagnosing TBDs; 7. Genetic Counseling Considerations; 8. Clinical Management; 8.1. Bone marrow failure; 8.2. Pulmonary fibrosis.
• 9. Summary and Future DirectionsAcknowledgments; References; Chapter Three: Telomere Biology in Stem Cells and Reprogramming; 1. Introduction; 1.1. A variety of stem cells throughout organismal development; 1.2. Telomeres cap chromosomal ends; 2. Telomere Homeostasis in Stem Cells; 2.1. Telomerase activity in pluripotent stem cells; 2.2. Telomerase activity in adult multipotent cells; 2.2.1. Hematopoietic system; 2.2.2. Hair follicle stem cells; 2.2.3. Intestinal stem cells; 2.2.4. Muscle stem cells; 2.2.5. Neural stem cells; 2.2.6. Spermatogonial stem cells.
• 2.3. Organismal consequences of telomere attrition in stem cells2.4. Noncanonical roles of telomerase in stem cell regulation; 3. Cellular Reprogramming; 3.1. Somatic cell nuclear transfer and cell fusion; 3.1.1. Telomere biology in SCNT; 3.2. Reprogramming through induced pluripotency; 3.2.1. Telomere reprogramming in iPS cells; 3.2.2. Derivation of IPS cells harboring disease-associated telomerase mutations; 4. Conclusions; References; Chapter Four: Telomere Dynamics and Aging.