Regulated cell death. Volume 545, Part B, Necroptotic, autophagic and other non-apoptotic mechanisms /

• Άλλοι συγγραφείς: Ashkenazi, Avi, Wells, James A. (James Allen), 1950-, Yuan, Junying
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: San Diego, CA : Academic Press, 2014.; Ã2014
• Σειρά: Methods in enzymology ; volume 545.
• Θέματα: Cell death.; Autophagic vacuoles.; HEALTH & FITNESS > Diseases > General.; MEDICAL > Clinical Medicine.; MEDICAL > Diseases.; MEDICAL > Evidence-Based Medicine.; MEDICAL > Internal Medicine.; Cell Death.; Autophagy.; Electronic books.

 This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches. 

 Assays for necroptosis and activity of RIP kinases -- IAP family of cell death and signaling regulators -- Activation of the NLRP3 inflammasome by proteins that signal for necroptosis -- Characterization of the ripoptosome and its components: implications for anti-inflammatory and cancer therapy -- Tools and techniques to study ligand-receptor interactions and receptor activation by TNF superfamily members -- Necrotic cell death in Caenorhabditis elegans -- Noncanonical cell death in the nematode Caenorhabditis elegans -- Autophagy and cell death in the fly -- Structural studies of death receptors -- Use of E2~ubiquitin conjugates for the characterization of ubitquitin transfer by RING E3 ligases such as the inhibitor of apoptosis proteins -- Muiltidimensional profiling in the invetigation of small-molecule-induced cell death.