Regulated cell death. Volume 545, Part B, Necroptotic, autophagic and other non-apoptotic mechanisms /

• Άλλοι συγγραφείς: Ashkenazi, Avi, Wells, James A. (James Allen), 1950-, Yuan, Junying
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: San Diego, CA : Academic Press, 2014.; Ã2014
• Σειρά: Methods in enzymology ; volume 545.
• Θέματα: Cell death.; Autophagic vacuoles.; HEALTH & FITNESS > Diseases > General.; MEDICAL > Clinical Medicine.; MEDICAL > Diseases.; MEDICAL > Evidence-Based Medicine.; MEDICAL > Internal Medicine.; Cell Death.; Autophagy.; Electronic books.

This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches.

Πίνακας περιεχομένων:

• Assays for necroptosis and activity of RIP kinases
• IAP family of cell death and signaling regulators
• Activation of the NLRP3 inflammasome by proteins that signal for necroptosis
• Characterization of the ripoptosome and its components: implications for anti-inflammatory and cancer therapy
• Tools and techniques to study ligand-receptor interactions and receptor activation by TNF superfamily members
• Necrotic cell death in Caenorhabditis elegans
• Noncanonical cell death in the nematode Caenorhabditis elegans
• Autophagy and cell death in the fly
• Structural studies of death receptors
• Use of E2~ubiquitin conjugates for the characterization of ubitquitin transfer by RING E3 ligases such as the inhibitor of apoptosis proteins
• Muiltidimensional profiling in the invetigation of small-molecule-induced cell death.