Proteomics in Biomedicine and Pharmacology /

• Άλλοι συγγραφείς: Donev, Rossen (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Waltham, Massachusetts : Academic Press, 2014.
• Έκδοση: First edition.
• Σειρά: Advances in protein chemistry and structural biology ; v. 95.
• Θέματα: Proteomics.; Pharmacology.; SCIENCE > Life Sciences > Biochemistry.; Electronic books.

Volume 95 of Advances in Protein Chemistry and Structural Biology focuses on advances in proteomic techniques and their application in biomedicine and pharmacology. This volume describes in detail the applications of these techniques in studying a number of diseases and specific protein modification...

Πίνακας περιεχομένων:

• Front Cover; Proteomics in Biomedicine and Pharmacology; Copyright; Contents; Contributors; Preface; Chapter One: Application of Cutting-Edge Proteomics Technologies for Elucidating Host-Bacteria Interactions; 1. Introduction; 2. Classical Proteomics Strategies for Biomedical Research in General; 2.1. Gel-based methods; 3. Gel-Free Methods; 3.1. Gel-free-labeling methods; 3.1.1. Chemical labeling; 3.1.2. Metabolic labeling; 3.2. Label-free and absolute quantification; 4. New Proteomic Methods in Looking for Bacterial Pathogens; 5. Proteomic Advances in Looking for Host Organisms; 6. Prospects.
• 3. Applications of Phosphoproteomics in Biomedicine3.1. Applications in cancer research; 3.2. Applications in stem cell research; 3.3. Applications in cardiac research; 3.4. Applications in immunity research; 4. Discussion; References; Chapter Three: Recent Advances in Mass Spectrometry-Based Glycoproteomics; 1. Introduction; 2. Glycoproteomic Profiling by MS; 2.1. Glycoproteomics methodology; 2.2. Affinity enrichment; 2.3. Glycoprotein digestion; 2.4. Glycan release; 2.5. Chromatographic separation and SPE; 2.6. Mass spectrometry; 2.7. Quantitation; 2.8. Bioinformatics.
• 3. MS-Based Glycoproteomics in Disease Research3.1. Cancer biomarker research; 3.2. Neurodegenerative disease research; 4. Concluding Remarks; Acknowledgments; References; Chapter Four: Proteomics and Proteogenomics Approaches for Oral Diseases; 1. Introduction; 2. An Integrated Proteogenomics Protocol for Personalized Dentistry; 2.1. Human samples; 2.1.1. Tissues; 2.1.2. Blood; 2.1.3. Dental plaque and oral biofilms; 2.1.4. Gingival crevicular fluid; 2.1.5. Saliva; 2.1.6. Oral rinse; 2.2. Bioinformatics analysis; 2.2.1. Bioinformatics resources; 2.2.2. Leader-gene algorithm.
• 2.3. Proteomics technologies, with a focus on the label-free tools2.3.1. Mass spectrometry; 2.3.2. Anodic porous alumina; 2.3.3. Nucleic acid programmable protein arrays; 3. Oral Diseases; 3.1. Dental caries; 3.2. Periodontitis; 3.3. Oral lichen planus; 3.4. Oral cancer; 4. Concluding Remarks; References; Chapter Five: Advances in Nanocrystallography as a Proteomic Tool; 1. Introduction; 2. Langmuir-Blodgett (LB)-Based Crystallization; 3. Comparison of LB-Based Crystallization with Other Techniques; 4. Fourier Transform Infrared (FTIR) Spectroscopy for Investigating LB-Films.