Annual reports in medicinal chemistry. Volume 49 /

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry with an emphasis on emerging topics in the biological sciences that are expected to provide the basis for entirely new future therapies. Reviews on hot topics of interest in small mo...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Άλλοι συγγραφείς: Desai, Manoj C. (Επιμελητής έκδοσης)
Μορφή: Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Amsterdam : Academic Press, an imprint of Elsevier, 2014.
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
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245 0 0 |a Annual reports in medicinal chemistry.  |n Volume 49 /  |c Manoj C. Desai, editor-in-chief. 
260 |a Amsterdam :  |b Academic Press, an imprint of Elsevier,  |c 2014. 
300 |a 1 online resource (623 pages) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
588 0 |a Print version record. 
504 |a Includes bibliographical references. 
520 |a Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry with an emphasis on emerging topics in the biological sciences that are expected to provide the basis for entirely new future therapies. Reviews on hot topics of interest in small molecule drug discovery heavily pursued by industrial research organizations</li><li>Provides preclinical information in the context of chemical structures. Knowledgeable section editors who evaluate invited reviews for scientific rigor. 
505 0 |a Personal essays. My experiences in the pharmaceutical industry / John J. Baldwin -- Adventures in medical chemistry : a career in drug discovery / William J. Greenlee -- section 1. Central nervous system diseases. Natural and sysnthetic neuroactive steroid modulators of GABA and NMDA receptors / Gabriel Martinez-Botella ... [et al.] -- Development of LRRK2 kinase inhibitors for Parkinson's disease / Paul Galatsis ... [et al.] -- Stimulating neurotrophin receptors in the treatment of neurodegenerative disorders / Gunnar Nordvall and Pontus Forsell -- section 2. Cardiovascular and metabolic diseases. Small-molecule modulators of GPR40 (FFA1) / Sean P. Brown and Joshua P. Taygerly -- Recent advances in the development of P2Y12 receptor antagonists as antiplatelet agents / Allorie T. Caldwell and E. Blake Watkins -- Current approaches to the treatment of atrial fibrillation / Heather Finlay 
508 |a Mer receptor tyrosine kinase : therapeutic opportunities in oncology, virology, and cardiovascular indications / Xiaodong Wang and Stephen Frye -- section 7. Topics in drug design and discovery. Disease-modifying agents for the treatment of cystic fibrosis / Bradley D. Tait and John P. Miller --Advancements in stapled peptide drug discovery & development / Vincent Guerlavais and Tomi K. Sawyer -- Cytochrome P450 enzyme metabolites in lead discovery and development / Sylvie E. Kandel, Larry C. Wienkers and Jed N. Lampe -- 8. Case histories and NCEs. Case history : Forxiga (dapagliflozin), a potent selective SGLT2 inhibitor for treatment of diabetes / William N. Washburn -- Case history : Kalydeco (VS-770, ivacaftor), a CFTR potentiator for the treatment of patients with cystic fibrosis and the G551D-CFTR mutation / Sabine Hadida ... [et al.] -- Case history : Xeljanz (tofacitinib citrate), a first-in-class janus kinase inhibitor for the treatment of rheumatoid arthritis / Mark E. Flanagan ... [et al.] -- New chemical entities entering phase III trials in 2013 / Gregory T. Notte -- To market, to market : 2013 / Joanne Bronson ... [et al.]. 
650 0 |a Clinical chemistry  |v Periodicals. 
650 0 |a Pharmaceutical chemistry  |v Periodicals. 
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650 7 |a Pharmaceutical chemistry.  |2 fast  |0 (OCoLC)fst01060115 
655 4 |a Electronic books. 
655 7 |a Periodicals.  |2 fast  |0 (OCoLC)fst01411641 
700 1 |a Desai, Manoj C.,  |e editor. 
776 0 8 |i Print version:  |a Desai, Manoj C.  |t Annual Reports in Medicinal Chemistry.  |d Burlington : Elsevier Science, 2014  |z 9780128001677 
856 4 0 |u https://www.sciencedirect.com/science/bookseries/00657743/49  |z Full Text via HEAL-Link