Protein kinase inhibitors in research and medicine. Volume 548 /

• Άλλοι συγγραφείς: Shokat, Kevan (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Amsterdam, Netherlands : Elsevier Academic Press, 2014.
• Έκδοση: First edition.
• Σειρά: Methods in enzymology ; v. 548.
• Θέματα: Protein kinases > Inhibitors.; Protein Kinases.; Electronic books.

Πίνακας περιεχομένων:

• Catalytic mechanisms and regulation of protein kinases / Zhihong Wang and Philip A. Cole
• A structural atlas of kinases inhibited by clinically approved drugs / Qi Wang, Julie A. Zorn, and John Kuriyan
• Fragment-based approaches to the discovery of kinase inhibitors / Paul N. Mortenson, Valerio Berdini, and Marc O'Reilly
• Targeting protein kinases with selective and semipromiscuous covalent inhibitors / Rand M. Miller and Jack Taunton
• The resistance tetrad : amino acid hotspots for kinome-wide exploitation of drug-resistant protein kinase alleles / Fiona P. Bailey, Veselin I. Andreev, and Patrick A. Eyers
• FLiK : a direct-binding assay for the identification and kinetic characterization of stabilizers of inactive kinase conformations / Jeffrey R. Simar and Daniel Rauh
• Discovery of allosteric Bcr-Abl inhibitors from phenotypic screen to clinical candidate / Nathanael S. Gray and Doriano Fabbro
• The logic and design of analog-sensitive kinases and their small molecule inhibitors / Michael S. Lopez, Joseph I. Kliegman, and Kevan M. Shokat.