Circadian medicine /
"Circadian rhythms, the biological oscillations based around our 24-hour clock, have a profound effect on human physiology and healthy cellular function. Circadian Rhythms: Health and Disease is a wide-ranging foundational text that provides students and researchers with valuable information on...
| Άλλοι συγγραφείς: | |
|---|---|
| Μορφή: | Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Hoboken, New Jersey :
John Wiley & Sons Inc.,
[2015]
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| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Title page; Table of Contents; List of Contributors; Preface; I: Fundamental Concepts; 1 Cytosolic and Transcriptional Cycles Underlying Circadian Oscillations; 1.1 Introduction; 1.2 Assembling the transcriptional feedback loop; 1.3 Keeping the transcriptional clockworks in tune; 1.4 Building posttranslational mechanisms into the circadian pacemaker; 1.5 Is the transcriptional clock paramount?; 1.6 Conclusion: cytoscillators, clocks and therapies; Acknowledgements; References; 2 Molecular Determinants of Human Circadian Clocks; 2.1 Molecular elements of human clocks: a brief review
- 2.2 Peripheral and central clocks2.3 Signaling to peripheral circadian clocks; 2.4 Human peripheral and central clocks; 2.5 Human genetics; 2.6 Technologies for measurement of human circadian clocks; 2.7 Cellular methods; 2.8 Omics-based methods to analyze human clocks; 2.9 Summary and outlook; References; 3 The Suprachiasmatic Nucleus (SCN): Critical Points; 3.1 SCN is site of master circadian pacemaker in mammals; 3.2 SCN receives photic information through a specialized light detection pathway; 3.3 SCN neurons are endogenous single cell oscillators that generate rhythms in neural activity
- 3.4 The SCN has circuit level organization that is just beginning to be unraveled3.5 Coupling with the SCN circuit is mediated by a set of peptides with VIP on top of the hierarchy; 3.6 SCN outputs; 3.7 SCN in aging and disease; References; 4 Sleep and Circadian Rhythms: Reciprocal Partners in the Regulation of Physiology and Behavior; 4.1 Introduction; 4.2 What is sleep; 4.3 Circadian regulation of sleep; 4.4 Reciprocity: sleep-wake feedback to the circadian clock; 4.5 Conclusions: Circadian clocks and sleep are intertwined processes; References
- 5 Circadian Regulation of Arousal and its Role in Fatigue5.1 Defining arousal; 5.2 Brain structures important for arousal; 5.3 Neurochemicals signaling the states of arousal; 5.4 Circadian regulation of the arousal system; 5.5 Influence of input pathways on circadian regulation of arousal; 5.6 Sustained states of fatigue: a disorder of the arousal network?; 5.7 Conclusions; References; II: Circadian Regulation of Major Physiological Systems; 6 Physiology of the Adrenal and Liver Circadian Clocks; 6.1 Introduction; 6.2 Circadian control of adrenal function
- 6.3 Circadian control of liver function6.4 Conclusion; Acknowledgements; References; 7 Nutrition and Diet as Potent Regulators of the Liver Clock; 7.1 Introduction; 7.2 Food is a "zeitgeber": The FEO in the brain; 7.3 The FEO in peripheral tissues; 7.4 What should we eat? What types of food can stimulate the peripheral clock?; 7.5 When should we eat? Application to human life science; 7.6 Circadian rhythm and obesity and diabetes; References; 8 The Cardiovascular Clock; 8.1 Introduction; 8.2 The vascular clock; 8.3 Circadian clock regulation of the endothelial cell layer of blood vessels
