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04481nam a2200661 4500 |
| 001 |
ocn904046276 |
| 003 |
OCoLC |
| 005 |
20170124072525.2 |
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m o d |
| 007 |
cr cnu|||unuuu |
| 008 |
150226s2015 gw ob 001 0 eng d |
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|a N$T
|b eng
|e rda
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| 019 |
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|a 961646872
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| 020 |
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|a 9783527680658
|q electronic bk.
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|a 9783527680665
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|a 9783527680672 (Epub)
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|a 3527680675 (Epub)
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|a 9783527680689 (mobi)
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|a 3527680683 (mobi)
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|z (OCoLC)962625293
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4 |
|a QH438.4.B55
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|
7 |
|a SCI
|x 007000
|2 bisacsh
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| 082 |
0 |
4 |
|a 572.86
|2 23
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| 049 |
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|a MAIN
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| 245 |
0 |
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|a Biomarker validation :
|b technological, clinical and commercial aspects /
|c edited by Harald Seitz and Sarah Schumacher.
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| 264 |
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|a Weinheim, Germany :
|b Wiley-VCH,
|c 2015.
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| 300 |
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|a 1 online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 588 |
0 |
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|a Vendor-supplied metadata.
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|a Includes bibliographical references and index.
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|a Related Titles; Title Page; Copyright; Table of Contents; List of Contributors; Chapter 1: Biomarkers -- Past and Future; 1.1 Introduction; 1.2 Definitions of Biomarkers; 1.3 Biomarkers in the Past; 1.4 Novel Molecules and Structural Classes of Biomarkers by New Technologies; 1.5 Biomarkers in Drug Research; 1.7 Summary and Outlook; References; Chapter 2: Quantitative Proteomics Techniques in Biomarker Discovery; 2.1 Introduction; 2.2 2D-Difference Gel Electrophoresis; 2.3 Mass Spectrometry-Based Proteomics; 2.4 MALDI Mass Spectrometry Imaging; 2.5 Conclusion; References
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|a Chapter 3: Biomarker Qualification: A Company Point of View3.1 Introduction; 3.2 Biomarker Uses; 3.3 Biomarker Types; 3.4 Validation vs. Qualification; 3.5 Strategic Choices in Business Models; 3.6 Validation of Analytical Methods; 3.7 Clinical Qualification of Candidate Biomarkers; 3.8 Biomarker Qualification in the 'omics Era; 3.9 An Example of a Biomarker Provider; 3.10 Conclusion; References; Chapter 4: Biomarker Discovery and Medical Diagnostic Imaging; 4.1 Introduction; 4.2 Factors to Consider in Biomarker Selection for Imaging
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|a 4.3 Defining the Insertion Point of the Assay and Its Business Case4.4 Practical In Vitro Methods Used to Identify Biomarkers; 4.5 Preclinical Models; 4.6 Preclinical Analysis Techniques; 4.7 Translational Considerations and Restrictions; 4.8 Other Uses of Preclinical Models; 4.9 Nuclear Imaging Infrastructure; 4.10 Image Processing; 4.11 Concluding Remarks; References; Chapter 5: Breath: An Often Overlooked Medium in Biomarker Discovery; 5.1 Introduction; 5.2 Breath Analysis Studies: Targets, Techniques, and Approaches; 5.3 Biomarker Confounders; 5.4 Biomarkers in Breath
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|a 5.5 Outlook for Breath AnalysisAcknowledgments; References; Chapter 6: HTA in Personalized Medicine Technologies; 6.1 Introduction; 6.2 Health Technology Assessment (HTA); 6.3 Validation and Evaluation of Biomarker Tests; 6.4 Health Technology Assessment of Personalized Medicine Technologies; 6.5 Concluding Remarks; References; Chapter 7: Bone Remodeling Biomarkers: New Actors on the Old Cardiovascular Stage; 7.1 Introduction; 7.2 Cardiovascular Disease and Osteoporosis: Common Risk Factors and Common Pathophysiological Mechanisms; 7.3 Biomarkers of Bone Health in CVD; 7.4 Conclusion
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|a Biochemical markers.
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| 650 |
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|a SCIENCE / Life Sciences / Biochemistry
|2 bisacsh
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| 650 |
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7 |
|a Biochemical markers.
|2 fast
|0 (OCoLC)fst00831950
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| 655 |
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|a Electronic books.
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| 655 |
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7 |
|a Electronic books.
|2 local
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| 655 |
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|a Electronic books.
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| 700 |
1 |
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|a Seitz, Harald,
|e editor.
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| 700 |
1 |
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|a Schumacher, Sarah,
|e editor.
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| 776 |
0 |
8 |
|i Print version:
|w (OCoLC)ocn904046276
|z 9783527680658
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| 856 |
4 |
0 |
|u https://doi.org/10.1002/9783527680658
|z Full Text via HEAL-Link
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| 994 |
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|a 92
|b DG1
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