The genetics of neurodevelopmental disorders /

• Άλλοι συγγραφείς: Mitchell, Kevin J. (Professor of genetics) (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, New Jersey : Wiley/Blackwell, [2015]
• Θέματα: Mental retardation > Genetics.; Developmental disabilities > Genetics.; MEDICAL / Gynecology & Obstetrics; Medical.; Intellectual Disability > genetics.; Developmental Disabilities > genetics.; Electronic books.

 Neurodevelopmental disorders arise from disturbances to various processes of brain development, which can manifest in diverse ways. They encompass many rare genetic syndromes as well as common, heritable conditions such as intellectual disability, autism, ADHD, schizophrenia and many types of epilepsy.The Genetics of Neurodevelopmental Disordersexaminesrecent revolutionary advances in our understanding of the genetics of these disorders, exploring both basic discoveries and the translation of new findings into the clinical setting. The book begins by examining the genetic architecture and etiology of neurodevelopmental disorders. It describes the striking recent progress in identifying pathogenic mutations, which are grouped here based on the neurodevelopmental processes impacted. Subsequent chapters consider the use of cellular and animal models to elucidate the cascading consequences of such mutations, from molecular and cellular levels to emergent effects on neural circuits, brain systems and subsequent psychological development. The text concludes by examining the important clinical implications of the recent advances in the field, from recognition of the genetic causes in individual patients to development of new treatments and interventions. A timely synthesis,The Genetics of Neurodevelopmental Disorders is a unique and essential resource for neuroscientists, geneticists, neurologists and psychiatrists and an accessible and up-to-date overview for medical and science students. 

 The genetic architecture of neurodevelopmental disorders / Kevin J. Mitchell -- Overlapping etiology of neurodevelopmental disorders / Eric Kelleher and Aiden Corvin -- The mutational spectrum of neurodevelopmental disorders / Nancy D. Merner, Patrick A. Dion and Guy A. Rouleau -- The role of genetic interactions in neurodevelopmental disorders / Jason H. Moore and Kevin J. Mitchell -- Developmental instability, mutation load, and neurodevelopmental disorders / Ronald A. Yeo and Steven W. Gangestad -- Environmental factors and gene-environment interactions / John McGrath -- The genetics of brain malformations / M. Chiara Manzini and Christopher A. Walsh -- Disorders of axon guidance / Heike Blockus and Alain Chédotal -- Synaptic disorders / Catalina Betancur and Kevin J. Mitchell -- Human stem cell models of neurodevelopmental disorders / Peter Kirwan and Frederick J. Livesey -- Animal models for neurodevelopmental disorders / Hala Harony-Nicolas and Joseph D. Buxbaum -- Cascading genetic and environmental effects on development : implications for intervention / Esha Massand and Annette Karmiloff-Smith -- Human genetics and clinical aspects of neurodevelopmental disorders / Gholson J. Lyon and Jason O'Rawe -- Progress toward therapies and interventions for neurodevelopmental disorders / Ayokunmi Ajentunmobi and Daniela Tropea.