Antitargets and drug safety /

• Other Authors: Urbán, László, Patel, Vinod F., Vaz, Roy J.
• Format: eBook
• Language: English
• Published: Weinheim : Wiley-VCH, 2015.
• Series: Methods and principles in medicinal chemistry ; v. 66.
• Subjects: Drug development.; Drugs > Design.; Drugs > Side effects.; Drug interactions.; Medicine.; MEDICAL > Pharmacology.; Electronic books.
• Physical Description: 1 online resource (1266 pages).
• Bibliography: Includes bibliographical references and index.
• ISBN: 9783527673643; 3527673644; 9783527673674; 3527673679
• DOI: 10.1002/9783527673643

With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing.