Translational ADMET for drug therapy : principles, methods, and pharmaceutical applications /

• Κύριος συγγραφέας: Yanni, Souzan (Συγγραφέας)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Hoboken, New Jersey : John Wiley & Sons, Inc., [2015]
• Θέματα: Pharmacokinetics.; Drugs > Metabolism > Pharmacokinetics.; MEDICAL / Pharmacology; Drug Evaluation, Preclinical.; Drug-Related Side Effects and Adverse Reactions.; Pharmaceutical Preparations > metabolism.; Medical.; Electronic books.

Serving as a practical handbook about ADMET for drug therapy, this book presents effective technologies, methods, applications, data interpretation, and decision-making tactics for pharmaceutical and preclinical scientists. Chapters cover case studies and in vivo, in vitro, and computational tools f...

Πίνακας περιεχομένων:

• Translational Concept and Determination of Drug Absorption
• Distribution: Principle, Methods, and Applications
• Metabolism: Principle, Methods, and Applications
• Excretion: Principle, Methods, and Applications for Better Therapy
• Drug-Drug Interaction: From Bench to Drug Label
• General Toxicology: Principle, Methods, and Applications
• Toxicokinetics and Toxicity Testing in Drug Development
• PBPK Modeling and In Silico Prediction for ADME and Drug-Drug Interaction
• Translational Tools toward Better Drug Therapy in Human Populations
• Phase 1-Phase 3 Clinical Studies, Procedures, Responsibilities, and Documentation
• Regulatory Submission: MIST and Drug Safety Assessment.