Profiles of drug substances, excipients and related methodology. Volume forty /

• Άλλοι συγγραφείς: Brittain, H. G. (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Amsterdam : Academic Press, 2015.
• Σειρά: Profiles of drug substances, excipients, and related methodology ; Volume 40.
• Θέματα: Drugs.; Excipients.; MEDICAL > Pharmacology.; Electronic books.

Volumes in this widely revered series present comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. This organizational structure meets the needs of the pharmaceut...

Πίνακας περιεχομένων:

• Front Cover; Profiles of Drug Substances, Excipients, and Related Methodology; Copyright; Contents; Preface to Volume 40; Chapter 1: Cinnarizine: Comprehensive Profile; 1. Description; 1.1. Nomenclature; 1.1.1. Systemic Chemical Names; 1.1.2. Nonproprietary Names; 1.1.3. Proprietary Names; 1.1.3.1. Cinnarizine; 1.1.3.2. Cinnarizine Hydrochloride; 1.1.3.3. Mixture with Vitamin B6; 1.2. Formulae; 1.2.1. Empirical Formula, Molecular Weight, and CAS Number; 1.2.2. Structural Formulae; 1.3. Elemental Analysis; 1.4. Appearance; 1.5. Uses and Applications; 2. Methods of Preparation.
• 3. Physical Characteristics3.1. Ionization Constant; 3.2. Solubility Characteristics; 3.3. X-Ray Powder Diffraction Pattern; 3.4. Thermal Method of Analysis; 3.4.1. Melting Behavior; 3.5. Spectroscopy; 3.5.1. Ultraviolet Spectroscopy; 3.5.2. Vibrational Spectroscopy; 3.5.3. Nuclear Magnetic Resonance Spectrometry; 3.5.3.1. 1H NMR Spectrum; 3.5.3.2. 13C NMR Spectrum; 3.5.4. Electron Impact Mass Spectrometry; 4. Methods of Analysis; 4.1. Compendial Methods; 4.1.1. British Pharmacopoeial Methods [9]; 4.1.1.1. Identification; 4.1.1.2. Tests; 4.1.1.3. Acidity or Alkalinity; 4.1.1.4. Loss on Drying.
• 4.1.1.5. Heavy Metals4.1.1.6. Sulfated Ash; 4.1.1.7. Assay; 4.1.1.8. Storage; 4.1.1.9. Impurities; 4.2. Reported Methods of Analysis; 4.2.1. Titrimetric Method; 4.2.2. Spectrophotometric Methods; 4.2.2.1. Ultraviolet Spectrometry; 4.2.2.2. Spectrofluorimetric Method; 4.2.2.3. Chemiluminescence Method; 4.2.3. Voltammetric Methods; 4.2.4. Polarographic Method; 4.2.5. Chromatographic Methods; 4.2.5.1. Thin-Layer Chromatography; 4.2.5.2. Gas Chromatography; 4.2.5.3. Gas Chromatography-Mass Spectrometric Method; 4.2.5.4. High-Performance Liquid Chromatographic Methods.
• 4.2.5.5. High-Performance Liquid Chromatography-Mass Spectrometry4.2.5.6. Capillary Electrophoresis; 5. Biological Analysis; 6. Stability; 7. Pharmacokinetics, Metabolism, and Excretion; 8. Pharmacology; Acknowledgment; References; Chapter 2: Glutathione; 1. Description; 1.1. Nomenclature; 1.1.1. Systematical Chemical Names; 1.1.2. Nonproprietary Name; 1.1.3. Proprietary Names; 1.2. Formulae; 1.2.1. Empirical Formula, Molecular Weight, and CAS Number; 1.2.2. Structural Formula; 1.3. Elemental Composition; 1.4. Appearance; 2. Uses and Applications; 3. Methods of Preparation.
• 3.1. History of Glutathione Structure[12]3.2. Biosynthesis of Glutathione; 3.3. Synthesis of Glutathione; 3.3.1. First Method; 3.3.2. Second Method; 4. Physical Characteristics; 4.1. Solubility; 4.2. X-ray Powder Diffraction Pattern; 4.3. Crystal Structure; 4.3.1. Determination of the Positions of the Sulfur Atoms in the Unit Cell; 4.3.2. The Cochran and Douglas Method [33] Applied to the c-Axis Projection; 4.3.3. The Use of the Heavy-Atom Technique; 4.3.4. The Refinement of the Structure; 4.4. Thermal Methods of Analysis; 4.4.1. Melting Behavior; 4.4.2. Differential Scanning Calorimetry.