Progress in molecular biology and translational science. volume 133, RGS protein physiology and pathophysiology /

• Άλλοι συγγραφείς: Fisher, Rory A. (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Waltham, MA : Academic Press, 2015.
• Έκδοση: First edition.
• Σειρά: Progress in molecular biology and translational science ; volume 133.
• Θέματα: G proteins.; G proteins > Analysis.; Molecular biology.; SCIENCE > Life Sciences > Biochemistry.; Electronic books.

RGS Protein Physiology and Pathophysiology describes the current, state-of-the-art research occurring in the laboratories of leaders in the RGS protein field that utilize genetic mouse models to interrogate the function of RGS proteins in vivo. Each chapter describes the elucidated role of a specifi...

Πίνακας περιεχομένων:

• Chapter Three: RGS Protein Regulation of Phototransduction1. Introduction; 2. From Photon to a Neural Signal: The Wonder of Phototransduction; 3. The Need for Speed: Discrepancy on G-Protein Shutoff During Phototransduction Recovery; 4. Cannot Do It Alone: The Transducin GAP Is a Protein Complex; 5. Translocation and Regulation of RGS9-1; 6. Conclusions: Emerging Functions of RGS Proteins in the Visual System; References; Chapter Four: Role of Regulators of G Protein Signaling Proteins in Bone Physiology and Pathophysiology; 1. Introduction to Bone; 2. The GPCR-G Protein-RGS Signaling Pathway.
• 2.1. The G Protein Complex2.2. Introduction to RGS Proteins; 3. RGS Proteins in Osteoblasts; 3.1. RGS2 in Osteoblasts; 3.2. RGS5 in Osteoblasts; 3.3. Axin in Osteoblasts; 4. RGS Proteins in Osteoclasts; 4.1. RGS10 in Osteoclasts; 4.2. RGS12 in Osteoclasts; 4.3. RGS18 in Osteoclasts; 5. GPCR-RGS Proteins Signaling in Skeletal Physiology; 5.1. RGS Proteins and PTH/PTHrP Signaling in Bone; 5.2. RGS Proteins and Wnt Signaling in Bone; 5.3. RGS Proteins and Ca2+ Oscillations; 6. GPCR/RGS Signaling in Skeletal Disorders; 6.1. PTH1R and GPCR 48 in Skeletal Development and Diseases.
• 6.2. CaSR in Skeletal Development and Disease6.3. The Canonical Wnt Signaling Pathway in Bone Disease; 6.3.1. Axin in Bone Development and Bone Disease; 6.3.2. Mouse Models of Wnt Signaling in Skeletal Homeostasis; 6.3.3. Bone Diseases of Defective Wnt Signaling; 6.4. RGS Proteins in Inflammatory Bone Disease; 7. Conclusion and Perspectives; Acknowledgments; References; Chapter Five: Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function; 1. Introduction; 2. Structure and Biochemical Functions of RGS2; 3. Regulation of RGS2 Expression.