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ocn936379394 |
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20180501122029.0 |
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m o d |
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cr cnu---unuuu |
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160202s2016 mau ob 001 0 eng d |
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|a N$T
|b eng
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|d IDEBK
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|a 939262123
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|a 9780128038680
|q electronic bk.
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|a 0128038683
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|a 9780128037867
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|a 0128037865
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|a (OCoLC)936379394
|z (OCoLC)939262123
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|a RC564
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|a HEA
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|a 616.86
|2 23
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|a TEFA
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|a The molecular basis of drug addiction /
|c edited by Shafiqur Rahman.
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|a Cambridge, MA :
|b Academic Press is an imprint of Elsevier,
|c [2016]
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|c Ã2016
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|a 1 online resource
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|a text
|b txt
|2 rdacontent
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|a computer
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|a online resource
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|a Progress in Molecular Biology and Translational Science ;
|v v. 137
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|a Online resource; title from PDF title page (EBSCO, viewed February 11, 2016)
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|a Includes bibliographical references and index.
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|a This volume of Progress in Molecular Biology and Translational Science focuses on the molecular basis of drug addiction.
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|a Cover; Title page; Copyright page ; Contents ; Contributors; Preface; Chapter One -- Molecular Mechanism: ERK Signaling, Drug Addiction, and Behavioral Effects ; Abstract; 1 Introduction; 2 ERK Signaling Pathway; 3 ERK Signaling and Drug Addiction; 3.1 Cocaine; 3.2 Amphetamine; 3.3 Methamphetamine; 3.4 Marijuana; 3.5 Nicotine; 3.6 Alcohol (Ethanol); 4 Conclusions and Future Directions; Acknowledgment; References; Chapter Two -- Ethanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings ; Abstract; 1 Alcoholism and Genetics
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|a 2 Central Glutamatergic Activity2.1 Metabotropic Glutamate Receptors ; 2.2 Ionotropic Glutamate Receptors ; 2.3 Glutamate Transporters and Carriers ; 2.4 Glutamate Synthesis and Metabolism ; 2.5 Glutamate and the Postsynaptic Density ; 3 Central Glutamate Activity and Alcohol Dependence; 3.1 Alcohol's Effects on Glutamate Activity and Extracellular Levels; 3.2 Metabotropic Glutamate Receptors and Alcohol; 3.3 Ionotropic Glutamate Receptors and Alcohol; 3.4 Glutamate Transporters/Carriers and Alcohol; 3.5 Glutamate-Associated Enzyme Activity and Alcohol
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|a 3.6 The Postsynaptic Density and Alcohol4 Glutamate-Associated Genetic Variations and Alcoholism; 5 Alcohol and Glutamate Gene Expression; 6 Alcohol-Associated Changes in Gene/Protein Expression of P Rats; 6.1 Metabotropic Glutamate Receptor Expression Differences ; 6.2 Ionotropic Glutamate Receptor Expression Differences ; 6.3 Expression Differences for Glutamate Transporters, Enzymes, and Postsynaptic Density ; 7 Conclusions; Acknowledgments; References; Chapter Three -- S-Glutathionylation and Redox Protein Signaling in Drug Addiction ; Abstract; 1 Introduction ; 2 Oxidative Stress
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|a 3 S-Glutathionylation of Proteins Occurs in Response to Oxidative Stress 4 S-Glutathionylation of Proteins is a Redox-Sensitive Signaling Mechanism in Cells ; 5 S-Glutathionylation in Addiction-Related Protein Signaling ; 5.1 Drug Addiction, Dopamine, and Oxidative Stress ; 5.2 Altered Neurotransmission in Response to Ethanol, Cocaine, and Opioids Share Common Signaling Mechanisms ; 6 S-Glutathionylation of PKA, PKC, Cdk5, and Actin May Influence Drug Behavior ; 7 S-Glutathionylation in Alcohol Addiction ; 7.1 Ethanol Metabolism Increases ROS Production
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|a 7.2 Increased ROS Production May Contribute to the Behavioral Effects of Ethanol 7.3 Protein S-Glutathionylation in Response to Ethanol ; 8 S-Glutathionylation in Cocaine Addiction ; 8.1 Cocaine Metabolism Increases ROS Production ; 8.2 Increased ROS Production May Contribute to the Behavioral Effects of Cocaine ; 8.3 Protein S-Glutathionylation in Response to Cocaine ; 9 S-Glutathionylation in Heroin Addiction ; 9.1 Heroin Metabolism Increases ROS Production ; 9.2 Increased ROS Production May Contribute to the Behavioral Effects of Heroin
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|a Substance abuse
|x Physiological aspects.
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|a Drug abuse
|x Molecular aspects.
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|a HEALTH & FITNESS / Diseases / General
|2 bisacsh
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|a MEDICAL / Clinical Medicine
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|a MEDICAL / Diseases
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|a MEDICAL / Evidence-Based Medicine
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|a MEDICAL / Internal Medicine
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|a Drug abuse
|x Molecular aspects.
|2 fast
|0 (OCoLC)fst00898510
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|a Substance abuse
|x Physiological aspects.
|2 fast
|0 (OCoLC)fst01136793
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|a Electronic books.
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|a Electronic books.
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|a Rahman, Shafiqur,
|d 1963-
|e editor.
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|i Print version:
|a Rahman, Shafiqur
|t The Molecular Basis of Drug Addiction
|d : Elsevier Science,c2016
|z 9780128037867
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|a Progress in molecular biology and translational science ;
|v v. 137.
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|u https://www.sciencedirect.com/science/bookseries/18771173/137
|z Full Text via HEAL-Link
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