Vitamin D Hormone /

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is rel...

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Άλλοι συγγραφείς: Litwack, Gerald (Επιμελητής έκδοσης)
Μορφή: Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Cambridge, MA : Academic Press is an Imprint of Elsevier, 2016.
Έκδοση:First edition.
Σειρά:Vitamins and hormones ; v. 100.
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
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245 0 0 |a Vitamin D Hormone /  |c series editor, Gerald Litwack. 
250 |a First edition. 
264 1 |a Cambridge, MA :  |b Academic Press is an Imprint of Elsevier,  |c 2016. 
300 |a 1 online resource (xviii, 483 pages :  |b color illustrations). 
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490 1 |a Vitamins and hormones ;  |v volume 100 
546 |a Text in English. 
588 0 |a Online resource; title from PDF title page (EBSCO, viewed February 9, 2016) 
520 |a First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on vitamin D hormone. 
505 0 |a Front Cover; Vitamin D Hormone; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Vitamin D: Historical Overview; 1. The Discovery of Vitamin D; 2. The Discovery of the Physiological Functions of Vitamin D; 3. The Discovery of the Hormonal Form of Vitamin D; 4. The Isolation of the Final Active Form of Vitamin D; 5. Discovery of the Vitamin D Endocrine System (Fig.5); 6. Other Metabolism of Vitamin D; 7. Discovery of the Vitamin D Receptor; References; Chapter Two: Genomic Determinants of Vitamin D-Regulated Gene Expression; 1. Introduction 
505 8 |a 2. Genome-Wide Analysis Reveals New Concepts in Vitamin D Action3. Novel Principles of Vitamin D Action; 3.1. Modes of DNA Binding and Implications for the Regulatory Activity of the VDR; 3.1.1. Ligand-Independent Function of the VDR in the Hair Cycle; 3.1.2. Ligand-Independent Suppression of Gene Expression by the VDR; 3.2. 1,25(OH)2D3 Regulates Transcription via Multiple Enhancers Located at Sites Distal to Gene Promoters; 3.2.1. Defining Gene Regulation from Distal Sites; 3.2.2. Confirming Enhancer Function at Target Genes 
505 8 |a 3.2.3. Application of the CRISPR/Cas9 Method to the Study of Gene Regulation4. The Influence of Cellular Differentiation on Vitamin D Activity; 4.1. Differentiation Is Accompanied by Direct Alterations in the VDR Cistrome; 4.2. The Impact of Osteoblast Differentiation on Master Regulatory Factor Distribution, Histone Modifying Activity, and R ...; 4.3. Identification and Structure of the Osteoblast Enhancer Complex; 5. VDR Modulates Histone Acetylation at Target Genes; 6. Summary; Acknowledgments; References; Chapter Three: Inhibitors for the Vitamin D Receptor-Coregulator Interaction 
505 8 |a 1. Introduction1.1. VDR Coactivators; 1.2. VDR Corepressors; 2. Peptide-Based Inhibitors of the VDR-Coregulator Interaction; 3. Small-Molecule Inhibitors of the VDR-Coregulator Interaction; 4. VDR Antagonists or Allosteric Inhibition of the VDR-Coregulators Interaction; 4.1. TEI-9647; 4.2. ZK159222; 4.3. ZK168281; 4.4. ZK191784; 4.5. Amide-Based VDR Antagonists; 4.6. Adamantane-Based VDR Antagonists; 4.7. Branched VDR Antagonists; 5. Conclusion and Future Directions; Acknowledgments; References; Chapter Four: Structural Studies of Vitamin D Nuclear Receptor Ligand-Binding Properties 
505 8 |a 1. Introduction2. Crystal Structures of VDR LBD in Complex with 1,25(OH)2D3; 2.1. Overall Organization of Human, Rat, and Zebrafish VDR-LBD Complexes; 2.2. Activation Function-2; 2.3. Recognition of Coactivator Peptide; 2.4. VDR Ligand-Binding Pocket; 3. Secosteroidal Derivatives of 1,25(OH)2D3; 3.1. Superagonists of VDR; 3.1.1. 20-Epi Derivatives; 3.1.2. C2-Substituted Analogs; 3.1.3. 14-Epi Analogs; 3.2. Synthetic Compounds Expanding the VDR LBP; 3.2.1. Gemini Analogs; 3.2.2. 22-Alkyl Derivatives; 3.2.3. Adamantyl-Containing Compounds; 4. Synthetic Mimics of 1,25(OH)2D3 
650 0 |a Vitamin D. 
650 0 |a Parathyroid hormone. 
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700 1 |a Litwack, Gerald,  |e editor. 
776 0 8 |i Print version:  |a Litwack, Gerald  |t Vitamin D Hormone  |d : Elsevier Science,c2016  |z 9780128048245 
830 0 |a Vitamins and hormones ;  |v v. 100. 
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