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05452nam a2200577 4500 |
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ocn936379408 |
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OCoLC |
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20180501122029.0 |
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m o d |
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cr cnu---unuuu |
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160202s2016 maua o 000 0 eng d |
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|a N$T
|b eng
|e rda
|e pn
|c N$T
|d IDEBK
|d YDXCP
|d EBLCP
|d N$T
|d OPELS
|d CDX
|d OCLCF
|d Z5A
|d CNCGM
|d OCLCQ
|d MEU
|d NLE
|d OCLCA
|d GrThAP
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|a 939262243
|a 953852533
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|a 9780128052402
|q electronic bk.
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|a 0128052406
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|a 9780128048245
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|a 0128048247
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|a (OCoLC)936379408
|z (OCoLC)939262243
|z (OCoLC)953852533
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|a QP772.V53
|b .V58 2016eb
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|a MED
|x 075000
|2 bisacsh
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|a SCI
|x 036000
|2 bisacsh
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|a 612.399
|2 23
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|a TEFA
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|a Vitamin D Hormone /
|c series editor, Gerald Litwack.
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|a First edition.
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|a Cambridge, MA :
|b Academic Press is an Imprint of Elsevier,
|c 2016.
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|a 1 online resource (xviii, 483 pages :
|b color illustrations).
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a Vitamins and hormones ;
|v volume 100
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|a Text in English.
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|a Online resource; title from PDF title page (EBSCO, viewed February 9, 2016)
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|a First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on vitamin D hormone.
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|a Front Cover; Vitamin D Hormone; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Vitamin D: Historical Overview; 1. The Discovery of Vitamin D; 2. The Discovery of the Physiological Functions of Vitamin D; 3. The Discovery of the Hormonal Form of Vitamin D; 4. The Isolation of the Final Active Form of Vitamin D; 5. Discovery of the Vitamin D Endocrine System (Fig.5); 6. Other Metabolism of Vitamin D; 7. Discovery of the Vitamin D Receptor; References; Chapter Two: Genomic Determinants of Vitamin D-Regulated Gene Expression; 1. Introduction
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|a 2. Genome-Wide Analysis Reveals New Concepts in Vitamin D Action3. Novel Principles of Vitamin D Action; 3.1. Modes of DNA Binding and Implications for the Regulatory Activity of the VDR; 3.1.1. Ligand-Independent Function of the VDR in the Hair Cycle; 3.1.2. Ligand-Independent Suppression of Gene Expression by the VDR; 3.2. 1,25(OH)2D3 Regulates Transcription via Multiple Enhancers Located at Sites Distal to Gene Promoters; 3.2.1. Defining Gene Regulation from Distal Sites; 3.2.2. Confirming Enhancer Function at Target Genes
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|a 3.2.3. Application of the CRISPR/Cas9 Method to the Study of Gene Regulation4. The Influence of Cellular Differentiation on Vitamin D Activity; 4.1. Differentiation Is Accompanied by Direct Alterations in the VDR Cistrome; 4.2. The Impact of Osteoblast Differentiation on Master Regulatory Factor Distribution, Histone Modifying Activity, and R ...; 4.3. Identification and Structure of the Osteoblast Enhancer Complex; 5. VDR Modulates Histone Acetylation at Target Genes; 6. Summary; Acknowledgments; References; Chapter Three: Inhibitors for the Vitamin D Receptor-Coregulator Interaction
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|a 1. Introduction1.1. VDR Coactivators; 1.2. VDR Corepressors; 2. Peptide-Based Inhibitors of the VDR-Coregulator Interaction; 3. Small-Molecule Inhibitors of the VDR-Coregulator Interaction; 4. VDR Antagonists or Allosteric Inhibition of the VDR-Coregulators Interaction; 4.1. TEI-9647; 4.2. ZK159222; 4.3. ZK168281; 4.4. ZK191784; 4.5. Amide-Based VDR Antagonists; 4.6. Adamantane-Based VDR Antagonists; 4.7. Branched VDR Antagonists; 5. Conclusion and Future Directions; Acknowledgments; References; Chapter Four: Structural Studies of Vitamin D Nuclear Receptor Ligand-Binding Properties
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|a 1. Introduction2. Crystal Structures of VDR LBD in Complex with 1,25(OH)2D3; 2.1. Overall Organization of Human, Rat, and Zebrafish VDR-LBD Complexes; 2.2. Activation Function-2; 2.3. Recognition of Coactivator Peptide; 2.4. VDR Ligand-Binding Pocket; 3. Secosteroidal Derivatives of 1,25(OH)2D3; 3.1. Superagonists of VDR; 3.1.1. 20-Epi Derivatives; 3.1.2. C2-Substituted Analogs; 3.1.3. 14-Epi Analogs; 3.2. Synthetic Compounds Expanding the VDR LBP; 3.2.1. Gemini Analogs; 3.2.2. 22-Alkyl Derivatives; 3.2.3. Adamantyl-Containing Compounds; 4. Synthetic Mimics of 1,25(OH)2D3
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|a Vitamin D.
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650 |
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|a Parathyroid hormone.
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650 |
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|a MEDICAL / Physiology
|2 bisacsh
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650 |
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|a SCIENCE / Life Sciences / Human Anatomy & Physiology
|2 bisacsh
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|a Parathyroid hormone.
|2 fast
|0 (OCoLC)fst01053221
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650 |
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|a Vitamin D.
|2 fast
|0 (OCoLC)fst01168206
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655 |
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|a Electronic books.
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655 |
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|a Electronic books.
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700 |
1 |
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|a Litwack, Gerald,
|e editor.
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776 |
0 |
8 |
|i Print version:
|a Litwack, Gerald
|t Vitamin D Hormone
|d : Elsevier Science,c2016
|z 9780128048245
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830 |
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|a Vitamins and hormones ;
|v v. 100.
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856 |
4 |
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|u https://www.sciencedirect.com/science/bookseries/00836729/100
|z Full Text via HEAL-Link
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