Vitamin D Hormone /
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is rel...
| Άλλοι συγγραφείς: | |
|---|---|
| Μορφή: | Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Cambridge, MA :
Academic Press is an Imprint of Elsevier,
2016.
|
| Έκδοση: | First edition. |
| Σειρά: | Vitamins and hormones ;
v. 100. |
| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Front Cover; Vitamin D Hormone; Copyright; Former Editors; Contents; Contributors; Preface; Chapter One: Vitamin D: Historical Overview; 1. The Discovery of Vitamin D; 2. The Discovery of the Physiological Functions of Vitamin D; 3. The Discovery of the Hormonal Form of Vitamin D; 4. The Isolation of the Final Active Form of Vitamin D; 5. Discovery of the Vitamin D Endocrine System (Fig.5); 6. Other Metabolism of Vitamin D; 7. Discovery of the Vitamin D Receptor; References; Chapter Two: Genomic Determinants of Vitamin D-Regulated Gene Expression; 1. Introduction
- 2. Genome-Wide Analysis Reveals New Concepts in Vitamin D Action3. Novel Principles of Vitamin D Action; 3.1. Modes of DNA Binding and Implications for the Regulatory Activity of the VDR; 3.1.1. Ligand-Independent Function of the VDR in the Hair Cycle; 3.1.2. Ligand-Independent Suppression of Gene Expression by the VDR; 3.2. 1,25(OH)2D3 Regulates Transcription via Multiple Enhancers Located at Sites Distal to Gene Promoters; 3.2.1. Defining Gene Regulation from Distal Sites; 3.2.2. Confirming Enhancer Function at Target Genes
- 3.2.3. Application of the CRISPR/Cas9 Method to the Study of Gene Regulation4. The Influence of Cellular Differentiation on Vitamin D Activity; 4.1. Differentiation Is Accompanied by Direct Alterations in the VDR Cistrome; 4.2. The Impact of Osteoblast Differentiation on Master Regulatory Factor Distribution, Histone Modifying Activity, and R ...; 4.3. Identification and Structure of the Osteoblast Enhancer Complex; 5. VDR Modulates Histone Acetylation at Target Genes; 6. Summary; Acknowledgments; References; Chapter Three: Inhibitors for the Vitamin D Receptor-Coregulator Interaction
- 1. Introduction1.1. VDR Coactivators; 1.2. VDR Corepressors; 2. Peptide-Based Inhibitors of the VDR-Coregulator Interaction; 3. Small-Molecule Inhibitors of the VDR-Coregulator Interaction; 4. VDR Antagonists or Allosteric Inhibition of the VDR-Coregulators Interaction; 4.1. TEI-9647; 4.2. ZK159222; 4.3. ZK168281; 4.4. ZK191784; 4.5. Amide-Based VDR Antagonists; 4.6. Adamantane-Based VDR Antagonists; 4.7. Branched VDR Antagonists; 5. Conclusion and Future Directions; Acknowledgments; References; Chapter Four: Structural Studies of Vitamin D Nuclear Receptor Ligand-Binding Properties
- 1. Introduction2. Crystal Structures of VDR LBD in Complex with 1,25(OH)2D3; 2.1. Overall Organization of Human, Rat, and Zebrafish VDR-LBD Complexes; 2.2. Activation Function-2; 2.3. Recognition of Coactivator Peptide; 2.4. VDR Ligand-Binding Pocket; 3. Secosteroidal Derivatives of 1,25(OH)2D3; 3.1. Superagonists of VDR; 3.1.1. 20-Epi Derivatives; 3.1.2. C2-Substituted Analogs; 3.1.3. 14-Epi Analogs; 3.2. Synthetic Compounds Expanding the VDR LBP; 3.2.1. Gemini Analogs; 3.2.2. 22-Alkyl Derivatives; 3.2.3. Adamantyl-Containing Compounds; 4. Synthetic Mimics of 1,25(OH)2D3
