Big on BK : current insights into the function of large conductance voltage- and Ca2+- activated K+ channels at the molecular, cellular and systemic levels /
Big on Bk: Current Insights into the Function of Large Conductance Voltage- and Ca2+- Activated K+ Channels at the Molecular, Cellular and Systemic Levels, a volume in the International Review of Neurobiology series, is a comprehensive overview of the state-of-the-art research into this area. It rev...
| Άλλοι συγγραφείς: | |
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| Μορφή: | Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Cambridge, MA :
Academic Press is an imprint of Elsevier,
2016.
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| Σειρά: | International review of neurobiology ;
v. 128. |
| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Front Cover; Big on BK: Current Insights into the Function of Large Conductance Voltage- and Ca2+-Activated K+ Channels at the Molecular ... ; Copyright; Contents; Contributors; Preface; Chapter One: Biophysics of BK Channel Gating; 1. Introduction; 2. Voltage-Dependent Gating in BK Channels; 2.1. Our Current Understanding of Voltage-Dependent Channel Gating; 2.2. Operation of the Noncanonical BK Channel VSD; 2.3. Modulation of BK Voltage-Dependent Gating; 3. Ligand-Dependent Gating in BK Channels; 3.1. Ca2+-Dependent Gating; 3.2. Mg2+-Dependent Gating; 4. The BK Allosteric Gating Mechanism.
- 4.1. The HCA and HA Models of Allosteric BK Channel Activation4.2. Electromechanical Coupling; 4.3. Modulation of Electromechanical Coupling; 4.4. Coupling Between the Ca2+ Sensors and the Gate; 4.5. Modulation of BK Ca2+ Sensitivity; 4.6. Coupling Between Voltage and Ca2+ Sensors; 4.7. Coupling Between RCK1 and RCK2 Ca2+ Sensors; 5. The Extraordinary Conductance of BK Channels; 6. Concluding Remarks: The BK Channel as a Rebel and a Model; Acknowledgments; References; Chapter Two: Modulation of BK Channel Function by Auxiliary Beta and Gamma Subunits; 1. Introduction; 2. Discovery.
