International review of cell and molecular biology. Volume 326 /

• Άλλοι συγγραφείς: Galluzzi, Lorenzo (Επιμελητής έκδοσης), Jeon, Kwang W. (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: London, United Kingdom : Academic Press is an imprint of Elsevier, 2016.
• Θέματα: Cytology.; Molecular biology.; SCIENCE / Life Sciences / Anatomy & Physiology; Electronic books.

International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. The series has a worldwide readership, maintaining its high standard by publishing invited articles on important and timely topics that are authored by prominent cell...

Πίνακας περιεχομένων:

• Cover ; Title Page; Copyright Page; Contents; Contributors; Dedication; Chapter One
• Sensing the Environment Through Sestrins: Implications for Cellular Metabolism ; Abstract; 1 Introduction; 2 Regulation and Function of Sestrins; 2.1 Regulation of Transcription of the Sestrin Family Members; 2.1.1 DNA Damage; 2.1.2 Oxidative Stress; 2.1.3 Nutrients and Oxygen Deprivation; 2.2 Sestrins as Antioxidant Proteins: Old Friends or New Foes?; 2.3 Sestrins are Regulators of mTOR; 2.3.1 The mTOR Complexes; 2.3.2 Regulation of mTORC1; 2.3.3 Sestrins Potentiate AMPK Activity
• 2.3.4 mTORC1 Regulation by the Sestrin-GATOR-Rags Axis2.3.5 Regulation of the mTORC2-Akt Pathway by Sestrins; 2.4 Sestrins and Autophagy; 2.4.1 Regulation of Autophagy; 2.4.2 Sestrins Promote Autophagy; 3 Sestrins are Sensors of Nutrient Availability and are Involved in Regulation of Metabolism; 3.1 Hypernutrition and Growth Factors; 3.2 Glucose; 3.3 Oxygen; 3.4 Amino Acids; 3.5 Lipids; 4 Conclusions and Perspectives; Acknowledgments; References; Chapter Two
• Metabolic Regulation of Apoptosis in Cancer ; Abstract; 1 Introduction; 2 Overview of Apoptosis Pathways; 2.1 Caspases
• 2.2 Intrinsic and Extrinsic Pathways2.3 Activation of Initiator Caspases; 2.4 Mitochondria Outer Membrane Permeabilization (MOMP); 3 Regulation of Apoptosis Through Glycolytic Pathway; 3.1 Hypoxia-Inducible Factor-1; 3.2 AKT; 3.3 BAD; 3.4 NOXA; 3.5 Caspase-2; 3.6 Cytochrome c; 4 p53 and Glucose Metabolism; 4.1 GLUT1/GLUT4 and HK2; 4.2 TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator); 4.3 Apoptosis-Inducing Factor and Synthesis of Cytochrome c Oxidase 2; 4.4 Glucose-6-Phosphate Dehydrogenase; 5 Regulation of Apoptosis by Lipid Metabolism; 5.1 Introduction of Sphingolipid Pathway
• 5.2 Pro-apoptotic Functions of Ceramide5.3 Role of Pathways That Regulate Ceramide Production; 5.3.1 Sphingomyelinase (SMase) Pathway; 5.3.2 De Novo Synthesis; 5.3.3 Salvage Pathway; 5.4 Fatty Acids; 6 Concluding Remarks; Acknowledgments; References; Chapter Three
• A Mechanistic Approach to the Development of Gene Therapy for Chronic Pain ; Abstract; 1 Introduction; 2 Basics of Gene Therapy; 2.1 Gene Transfer Mechanisms; 2.2 Various Viral Vectors and Their Characteristics; 3 Physiological Mechanisms of Nociception/Pain
• 3.1 Detection and Transmission of Nociceptive Signals Through the Nervous System3.1.1 From the Periphery to the SC; 3.1.2 Transmission at the First Relay, the SC; 3.1.3 Ascending Pathways and the Supraspinal Processing of Pain; 3.2 The Modulatory Systems of Pain Transmission; 3.2.1 Spinal Control of Pain, or the Gate-Control Theory; 3.2.2 Supraspinal Control of Pain, or the Descending Inhibitory Pathway; 4 Chronic Neuropathic Pain; 4.1 Anatomical, Cellular, and Molecular Basis of Neuropathic Pain; 4.2 Gene Therapy for Neuropathic Pain; 4.3 Perspectives on Gene Therapy for Neuropathic Pain