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04911nam a2200577 4500 |
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ocn958388037 |
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OCoLC |
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20180501122032.0 |
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m o d |
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160917s2016 mou o 000 0 eng d |
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|a EBLCP
|b eng
|e pn
|c EBLCP
|d OPELS
|d OCLCQ
|d IDEBK
|d N$T
|d OCLCQ
|d OCLCF
|d OCLCQ
|d GrThAP
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|a 9780128041581
|q (electronic bk.)
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|a 0128041587
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|a 9780128041406
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|a (OCoLC)958388037
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|a RC269.5
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|a HEA
|x 039000
|2 bisacsh
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|a MED
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|a 616.99/407
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|a TEFA
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|a Molecular and cellular basis of metastasis /
|c edited by Danny R. Welch and Paul B. Fisher.
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|a Saint Louis :
|b Elsevier Science,
|c 2016.
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| 300 |
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|a 1 online resource (392 pages).
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|a text
|b txt
|2 rdacontent
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|a computer
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|2 rdamedia
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|a online resource
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|a Advances in Cancer Research ;
|v volume 132
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|a Front Cover; Molecular and Cellular Basis of Metastasis: Road to Therapy; Copyright; Contents; Contributors; Preface; Chapter One: Detecting Tumor Metastases: The Road to Therapy Starts Here; 1. Introduction; 2. Preclinical In Vitro and In Vivo Models of Metastasis; 2.1. In Vitro Models; 2.2. In Vivo Models; 3. Approaches Currently Used to Detect Metastatic Lesions (on a Preclinical Level); 3.1. Lab Tests/Histopathology; 3.2. Noninvasive Blood Tests; 3.3. Small Animal Imaging; 3.4. Molecular-Genetic Imaging (Promoter-Based Protocols); 3.5. Circulating Tumor Cells.
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|a 4. Approaches Used to Detect Metastatic Lesions (on a Clinical Level)4.1. Biomarkers for Metastasis; 4.2. Imaging Procedures; 4.3. Circulating Tumor Cells; 5. Metastasis Detection/Therapy: Combining Imaging with Therapy (Theranostics); 6. Challenges Faced in Detecting Metastatic Cells; 7. Conclusions and Future Directions; Acknowledgments; References; Chapter Two: The Relationship Between Dormant Cancer Cells and Their Microenvironment; 1. Introduction; 2. Models to Study Tumor Cell Dormancy; 3. Intrinsic and Extrinsic Signals Converge to Induce Tumor Cell Dormancy.
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|a 4. Cooperative Extrinsic Signals Induce Dormancy Within the Bone Microenvironment5. Endosteal and Perivascular Niches Support Cancer Cell Dormancy; 6. Reactivation from Dormancy; 7. The Immune System and Dormancy; 8. Summary and Outlook; References; Chapter Three: Defining the Influence of Germline Variation on Metastasis Using Systems Genetics Approaches; 1. Introduction; 2. Hereditary Factors Associated with Cancer Aggressiveness and Metastasis in Human Populations; 2.1. Epidemiological Analysis; 2.2. Genetic Analysis Human Cohorts.
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|a 3. Systems Genetics Approaches to Identify Hereditary Modifiers of Metastasis3.1. Breast Cancer; 3.2. Prostate Cancer; 3.3. Melanoma; 4. Conclusions; Acknowledgments; References; Chapter Four: Breast Cancer Metastasis Suppressor 1 (BRMS1): Robust Biological and Pathological Data, But Still Enigmatic ... ; Concluding Thoughts; Acknowledgments; References; Chapter Five: Immune Regulation of the Metastatic Process: Implications for Therapy; 1. Introduction; 2. Key Players; 2.1. Monocytes; 2.2. Macrophages; 2.3. Neutrophils; 2.4. T Lymphocytes; 2.5. Natural Killer Cells.
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|a 3. Invasion and Intravasation3.1. Macrophages; 3.2. Neutrophils; 3.3. T Lymphocytes; 4. Survival and Extravasation; 4.1. Monocytes; 4.2. Neutrophils; 4.3. T Lymphocytes; 4.4. NK Cells; 5. Ectopic Growth; 5.1. Macrophages; 5.2. Neutrophils; 5.3. T Lymphocytes; 5.4. NK Cells; 6. Therapeutic Implications; Acknowledgments; References; Chapter Six: MicroRNA and Metastasis; 1. MicroRNAs; 1.1. Noncoding RNAs and the Discovery of MicroRNAs; 1.2. miRNA Biogenesis and Mechanisms of Action; 1.3. miRNA Functions; 2. miRNAs in Cancer; 2.1. Deregulated Expression of miRNAs in Cancer.
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|a 2.2. miRNAs as Oncogenes or Tumor Suppressors.
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|a Print version record.
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| 650 |
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|a Metastasis.
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|a HEALTH & FITNESS
|x Diseases
|x General.
|2 bisacsh
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| 650 |
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|a MEDICAL
|x Clinical Medicine.
|2 bisacsh
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7 |
|a MEDICAL
|x Diseases.
|2 bisacsh
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|a MEDICAL
|x Evidence-Based Medicine.
|2 bisacsh
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|a MEDICAL
|x Internal Medicine.
|2 bisacsh
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| 650 |
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|a Metastasis.
|2 fast
|0 (OCoLC)fst01018329
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| 655 |
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|a Electronic books.
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| 700 |
1 |
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|a Welch, Danny R.
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| 700 |
1 |
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|a Fisher, Paul B.
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| 776 |
0 |
8 |
|i Print version:
|a Welch, Danny R.
|t Molecular and Cellular Basis of Metastasis: Road to Therapy.
|d Saint Louis : Elsevier Science, ©2016
|z 9780128041406
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| 830 |
|
0 |
|a Advances in Cancer Research ;
|v v. 132.
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| 856 |
4 |
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|u https://www.sciencedirect.com/science/bookseries/0065230X/132
|z Full Text via HEAL-Link
|
