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04619nam a2200517 4500 |
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ocn959951527 |
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OCoLC |
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20180501122033.0 |
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m o d |
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cr |n||||||||| |
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161005s2016 mau o 001 0 eng d |
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|a YDX
|b eng
|e pn
|c YDX
|d N$T
|d IDEBK
|d EBLCP
|d OPELS
|d N$T
|d OCLCF
|d OCLCQ
|d QCL
|d OCLCQ
|d UPM
|d OCLCQ
|d MERUC
|d D6H
|d GrThAP
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| 019 |
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|a 960029505
|a 960087105
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| 020 |
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|a 9780128051153
|q (electronic bk.)
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| 020 |
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|a 0128051159
|q (electronic bk.)
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| 020 |
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|a 9780128047361
|q (print)
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| 020 |
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|a 0128047364
|q (print)
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| 035 |
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|a (OCoLC)959951527
|z (OCoLC)960029505
|z (OCoLC)960087105
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| 050 |
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4 |
|a QR399
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| 072 |
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7 |
|a SCI
|x 008000
|2 bisacsh
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| 072 |
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7 |
|a SCI
|x 045000
|2 bisacsh
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| 082 |
0 |
4 |
|a 579.2/56
|2 23
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| 049 |
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|a TEFA
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| 245 |
0 |
0 |
|a Coronaviruses /
|c edited by John Ziebuhr.
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| 260 |
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|a Cambridge, MA :
|b Academic Press,
|c Ã2016.
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| 300 |
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|a 1 online resource.
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| 336 |
|
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Advances in virus research ;
|v volume 96
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| 505 |
0 |
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|a Front Cover; Coronaviruses; Copyright; In Memoriam; Contents; Contributors; Preface; Chapter One: Supramolecular Architecture of the Coronavirus Particle; 1. Introduction; 2. Virion Structure and Durability; 3. Viral Proteins in Assembly and Fusion; 3.1. Membrane Protein; 3.2. Nucleoprotein; 3.3. Envelope Protein; 3.4. Spike Protein; 4. Evolution of the Structural Proteins; References; Chapter Two: Coronavirus Spike Protein and Tropism Changes; 1. Introduction; 2. Structure of the Coronavirus S Protein; 2.1. Structure of the S1 Subunit; 2.2. Structure of the S2 Subunit.
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| 505 |
8 |
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|a 3. Spike-Receptor Interactions3.1. Different Domains Within S1 May Act as RBD; 3.2. CoV Protein Receptor Preference; 4. S Protein Proteolytic Cleavage and Conformational Changes; 5. Tropism Changes Associated with S Protein Mutations; 5.1. S1 Receptor Interactions Determining Tropism; 5.1.1. S1 NTR Changes; 5.1.2. S1 CTR Changes; 5.2. Changes in Proteolytic Cleavage Site and Other S2 Mutations Associated with Altered Tropism; 5.2.1. Changes in Proteolytic Cleavage Sites; 5.2.2. Other S2 Mutations Associated with Altered Tropism; 6. Concluding Remarks; Acknowledgments; References.
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| 505 |
8 |
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|a Chapter Three: The Nonstructural Proteins Directing Coronavirus RNA Synthesis and Processing1. Introduction; 2. Coronavirus nsp7-10: Small but Critical Regulatory Subunits?; 2.1. Coronavirus nsp7; 2.2. Coronavirus nsp8 and nsp7-nsp8 Complexes; 2.3. Coronavirus nsp9; 2.4. Coronavirus nsp10; 3. Coronavirus nsp12: A Multidomain RNA Polymerase; 3.1. The nsp12 RdRp Domain; 3.2. The Initiation Mechanism of the nsp12 RdRp; 3.3. Inhibitors of the nsp12 RdRp; 3.4. The nsp12 NiRAN Domain; 4. Coronavirus nsp13: A Multifunctional and Highly Conserved Helicase Subunit.
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| 505 |
8 |
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|a 4.1. The Coronavirus nsp13 SF1 Helicase (HEL1)4.2. The Helicase-Associated ZBD; 4.3. Nidovirus Helicase Structural Biology; 4.4. Functional Characterization of the Nidovirus Helicase; 4.5. The Coronavirus Helicase as Drug Target; 5. The Coronavirus Capping Machinery: nsp10-13-14-16; 5.1. The nsp13 RNA 5' Triphosphatase; 5.2. The Elusive RNA GTase; 5.3. The nsp14 N7-Methyl Transferase; 5.4. The nsp16 2'-O-Methyl Transferase; 6. Coronavirus nsp14 ExoN: Key to a Unique Mismatch Repair Mechanism That Promotes Fidelity; 7. Coronavirus nsp15: A Remarkable Endoribonuclease with Elusive Functions.
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| 505 |
8 |
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|a 8. Summary and Future PerspectivesAcknowledgments; References; Chapter Four: Coronavirus cis-Acting RNA Elements; 1. Introduction; 2. Coronavirus Genome Replication and Transcription; 3. Coronavirus cis-Acting RNA Elements; 3.1. 5-Terminal cis-Acting RNA Elements; 3.1.1. Structural Features of Coronavirus 5'-Terminal cis-Acting Elements; 3.1.2. Functional Roles of Coronavirus 5'-Terminal cis-Acting Elements; 3.1.2.1. Stem-Loops 1 and 2; 3.1.2.2. Stem-Loop 3; 3.1.2.3. Stem-Loop 4; 3.1.2.4. Stem-Loop 5; 3.2. 3'-Terminal cis-Acting RNA Elements.
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| 500 |
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|a Includes index.
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| 588 |
0 |
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|a Print version record.
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| 650 |
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0 |
|a Coronaviruses.
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| 650 |
|
7 |
|a SCIENCE
|x Life Sciences
|x Biology.
|2 bisacsh
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| 650 |
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7 |
|a SCIENCE
|x Life Sciences
|x Microbiology.
|2 bisacsh
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| 650 |
|
7 |
|a Coronaviruses.
|2 fast
|0 (OCoLC)fst00879585
|
| 655 |
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4 |
|a Electronic books.
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| 700 |
1 |
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|a Ziebuhr, John,
|e editor.
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| 776 |
0 |
8 |
|i Print version:
|z 9780128047361
|z 0128047364
|w (OCoLC)950450190
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| 830 |
|
0 |
|a Advances in virus research ;
|v v. 96.
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| 856 |
4 |
0 |
|u https://www.sciencedirect.com/science/bookseries/00653527/96
|z Full Text via HEAL-Link
|
