T-box genes in development and disease /

Λεπτομέρειες βιβλιογραφικής εγγραφής
Άλλοι συγγραφείς: Frasch, Manfred (Επιμελητής έκδοσης)
Μορφή: Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Cambridge, MA : Academic Press, 2017.
Σειρά:Current topics in developmental biology ; v. 122.
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
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490 1 |a Current topics in developmental biology ;  |v volume 122 
588 0 |a Print version record. 
505 0 |a Front Cover; T-box Genes in Development; Copyright; Contents; Contributors; Preface; References; Chapter One: Evolution and Classification of the T-Box Transcription Factor Family; 1. An Updated Phylogenetic Classification of the T-Box Gene Family; 2. Premetazoan T-Box Genes; 3. Metazoan T-Box Classes and Function; 3.1. Brachyury; 3.2. Eomes/Tbrain; 3.3. Tbx7; 3.4. Tbx8; 3.5. Tbx2/3; 3.6. Tbx4/5; 3.7. Tbx1/15/20; 3.8. Tbx6; 4. Functional Conservation of Premetazoan and Early-Metazoan Brachyury Homologs; 5. Ancestral Conserved Role of Brachyury in Morphogenetic Movements. 
505 8 |a 6. The Evolution of T-Box RegulationAcknowledgments; References; Chapter Two: The Remarkably Diverse Family of T-Box Factors in Caenorhabditis elegans; 1. Introduction; 2. T-Box Genes in C. elegans and Related Nematodes; 3. DNA-Binding Specificity of C. elegans T-Box Factors; 4. Genetic Analyses of T-Box Factor Function in C. elegans; 4.1. A Network of T-Box Factors Function in C. elegans Pharyngeal Development; 4.2. tbx-2 Has Additional Functions in Neuronal Development and Sensory Adaptation. 
505 8 |a 4.3. The Tbx-1 Subfamily Members MAB-9 and MLS-1 Function Postembryonically to Specify Ectodermal and Muscle Cell Fates4.4. The TBX-8 and TBX-9 Paralogs Play Redundant Roles in Hypodermal and Body Wall Muscle Morphogenesis; 4.5. The Divergent T-Box Factor SEA-1 Functions as an Autosomal Counting Element to Determine Sex in C. elegans; 4.6. The Functions of Other C. elegans T-Box Genes Are Only Beginning to Be Characterized; 5. Posttranslational Mechanisms Affecting T-Box Factor Activity; 6. Concluding Remarks; Acknowledgments; References. 
505 8 |a Chapter Three: T-Box Genes and Developmental Gene Regulatory Networks in Ascidians1. Introduction; 2. Brachyury and the Temporal Control of Notochord Specification, Development, and Differentiation; 3. Tbx2/3: An Essential Mediator of Brachyury Function in the Notochord; 4. The Lineage-Specific Duplication of Tbx6 Genes in Ascidians; 5. Tbx6a; 6. Tbx6b, Tbx6c, and the Interpretation of the Maternally Inherited Muscle Determinant; 7. Tbx6b and Tbx6c in Heart Development; 8. Tbx1/10 and the Evolutionary Origins of the Pharyngeal Muscles. 
505 8 |a 9. Tbx15/18/22 (VegTR) and the Establishment of Muscle Cell Identity10. Maternal T and Tail Development; 11. Tbx20: In or Out of the Ascidian Heart?; 12. Transcriptional Regulation of T-Box Genes Expression; 12.1. Brachyury: A Balancing Act Between Multiple Activators and a Repressor; 12.2. Tbx2/3: A Composite Expression Pattern Orchestrated by Additive, Partly Redundant CRMs; 12.3. Tbx6b and Tbx6c: Early and Late Elements, Autoregulation, and Crossregulation; 13. Concluding Remarks; Acknowledgments; References. 
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650 0 |a Developmental genetics. 
650 0 |a Medical genetics. 
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650 7 |a Genes.  |2 fast  |0 (OCoLC)fst00939991 
650 7 |a Medical genetics.  |2 fast  |0 (OCoLC)fst01014133 
655 4 |a Electronic books. 
700 1 |a Frasch, Manfred,  |e editor. 
776 0 8 |i Print version:  |t T-box genes in development and disease.  |d Cambridge, MA : Academic Press, 2017  |z 012801380X  |z 9780128013809  |w (OCoLC)959033404 
830 0 |a Current topics in developmental biology ;  |v v. 122. 
856 4 0 |u https://www.sciencedirect.com/science/bookseries/00702153/122  |z Full Text via HEAL-Link