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ocn974372364 |
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OCoLC |
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20180501122035.0 |
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m o d |
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cr cnu|||unuuu |
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170302s2017 mau o 000 0 eng d |
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|a N$T
|b eng
|e rda
|e pn
|c N$T
|d OPELS
|d N$T
|d IDEBK
|d EBLCP
|d YDX
|d OCLCF
|d OCLCO
|d IAT
|d OCLCO
|d OCLCQ
|d OCLCO
|d CUS
|d OCLCO
|d GrThAP
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|a 974028372
|a 974312857
|a 974471958
|a 974547268
|a 974684517
|a 974750229
|a 974955427
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|a 9780128016244
|q (electronic bk.)
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|a 0128016248
|q (electronic bk.)
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|a 9780128015131
|q (print)
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|a 0128015136
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| 035 |
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|a (OCoLC)974372364
|z (OCoLC)974028372
|z (OCoLC)974312857
|z (OCoLC)974471958
|z (OCoLC)974547268
|z (OCoLC)974684517
|z (OCoLC)974750229
|z (OCoLC)974955427
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4 |
|a QP606.P76
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|a QU 141
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| 072 |
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|a SCI
|x 007000
|2 bisacsh
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|a 572/.792
|2 23
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|a TEFA
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| 245 |
0 |
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|a Protein kinases in development and disease /
|c edited by Andreas Jenny.
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| 264 |
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1 |
|a Cambridge, MA :
|b Academic Press is an imprint of Elsevier,
|c 2017.
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| 300 |
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|a 1 online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Current topics in developmental biology ;
|v volume 123
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0 |
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|a Online resource; title from PDF title page (ScienceDirect, viewed March 3, 2017).
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|a Front Cover; Protein Kinases in Development and Disease; Copyright; Contents; Contributors; Preface; References; Chapter One: WNK Kinases in Development and Disease; 1. Introduction; 2. The WNK-SPAK/OSR1 Kinase Cascade: Roles in Physiology and Disease; 2.1. Overview of the WNK-SPAK/OSR1 Kinase Cascade; 2.2. WNK-SPAK/OSR1 Signaling in Invertebrates; 2.2.1. WNK-SPAK/OSR1 Signaling Regulates NKCC in Drosophila Renal Tubule Function; 2.2.2. WNK-SPAK/OSR1 Signaling in C. elegans and Chloride Channel Regulation; 2.3. WNK-SPAK/OSR1 Signaling in Osmoregulation
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8 |
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|a 2.4. The Role of Mouse Protein-25 in WNK-SPAK/OSR1 Signaling3. Emerging Functions of the WNK Signaling Axis in Development; 3.1. Mammalian WNKs; 3.2. Zebrafish Wnk1a/b Have Roles in Angiogenesis and Neural Development; 3.3. Insights from the Drosophila Wnk-Frayed Axis; 3.3.1. A Conserved Role of Wnk in the Activation of Arrowhead/Lhx8; 3.3.2. Wnk in Wnt Signaling; 3.3.3. Intriguing Issues to Be Addressed; 4. Functions of WNKs in Cancer; 5. Conclusions; Acknowledgments; References; Chapter Two: SGK1: The Dark Side of PI3K Signaling; 1. Introduction: The Glucocorticoid-Regulated Kinase Family
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|a 2. SGK1: Expression and Stability Control3. SGK1 Is Activated in a PI3K-Dependent Manner; 4. AKT and SGK1: Target Overlap and Selectivity; 5. Roadblocks to Defining Specific SGK1 Functions; 6. SGK1 in Development and Differentiation; 6.1. Ion Transport; 6.2. Implantation and Pregnancy; 6.3. Myocardial Injury; 6.4. Muscle Mass; 6.5. T Cell Activation; 6.6. Macrophage Motility and Function; 6.7. Insulin Sensitivity; 7. SGK1 and Cancer; 8. Concluding Remarks; Acknowledgments; References; Chapter Three: Homeodomain-Interacting Protein Kinases: Diverse and Complex Roles in Development and Disease
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8 |
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|a 1. Introduction1.1. Hipk Protein Family; 1.2. Dynamic Tissue-Specific and Intracellular Localization of Hipk Proteins; 2. Requirements for Hipk Proteins During Development; 2.1. Regulation of Cell Proliferation and Cell Death; 2.2. Neuronal Development and Survival; 2.3. Angiogenesis and Hematopoiesis; 3. Hipk Roles in Regulation of Diverse Signaling Pathways; 3.1. Hipk Antagonizes the Global Corepressor Gro; 3.2. Modulating the Cellular Response to DNA Damage Through p53; 3.3. Regulation of Wnt Signaling by Hipks; 3.4. Hipk Promotes Yki Activity in the Hippo Pathway
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8 |
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|a 3.5. JNK Signaling Is Modulated Through Hipk3.6. Hipk Is Required for JAK/STAT Activity in Normal Development and Tumorigenesis; 4. Regulation of Hipk Activity; 4.1. Phosphorylation; 4.2. SUMO Modification; 4.3. Ubiquitin and Proteasomal Degradation; 4.4. Acetylation; 4.5. Regulation of Hipk Gene Expression; 4.6. Drug-Based Inhibition of Hipk; 5. Hipks in Disease; 5.1. Hipks as Tumor Suppressors in Cancer; 5.2. Hipks as Oncogenic Factors in Cancer; 5.3. Hipks and Fibrosis; 6. Conclusions; Acknowledgments; References; Chapter Four: ROR-Family Receptor Tyrosine Kinases
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| 650 |
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|a Protein kinases.
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| 650 |
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7 |
|a SCIENCE / Life Sciences / Biochemistry
|2 bisacsh
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| 650 |
|
7 |
|a Protein kinases.
|2 fast
|0 (OCoLC)fst01079695
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| 650 |
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2 |
|a Protein Kinases.
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| 655 |
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4 |
|a Electronic books.
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| 700 |
1 |
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|a Jenny, Andreas
|c (Biochemist),
|e editor.
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| 776 |
0 |
8 |
|i Print version:
|t Protein kinases in development and disease.
|b First edition.
|d Cambridge, MA : Elsevier/Academic Press, 2017
|z 9780128015131
|w (DLC) 2017394279
|w (OCoLC)988170443
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| 830 |
|
0 |
|a Current topics in developmental biology ;
|v v. 123.
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| 856 |
4 |
0 |
|u https://www.sciencedirect.com/science/bookseries/00702153/123
|z Full Text via HEAL-Link
|
