Nuclear receptors in development and disease /

• Άλλοι συγγραφείς: Forrest, Douglas (Molecular biologist) (Επιμελητής έκδοσης), Tsai, Sophia (Επιμελητής έκδοσης)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Cambridge, MA : Academic Press is an imprint of Elsevier, 2017.
• Σειρά: Current topics in developmental biology ; v. 125.
• Θέματα: Nuclear receptors (Biochemistry); SCIENCE / Life Sciences / Biochemistry; Electronic books.

Πίνακας περιεχομένων:

• AcknowledgmentsReferences; Chapter Three: Nuclear Receptors in Skeletal Homeostasis; 1. Introduction; 1.1. Bone and Bone Cells; 1.2. Nuclear Receptors; 2. NRs and Bone Homeostasis; 2.1. Estrogen Receptor; 2.1.1. Estrogens and Bone Health; 2.1.2. ER Knockout Models; 2.1.3. Mechanisms; 2.2. Androgen Receptor; 2.3. Glucocorticoid Receptor; 2.4. Peroxisome Proliferator-Activated Receptor; 2.4.1. Peroxisome Proliferator-Activated Receptor [alpha]; 2.4.2. Peroxisome Proliferator-Activated Receptor [delta]/[beta]; 2.4.3. Peroxisome Proliferator-Activated Receptor [gamma]; 2.5. Vitamin D Receptor
• 2.6. Retinoid Acid Receptor and RXR2.7. Estrogen Receptor-Related Receptor; 2.8. NR4A Orphan NRs; 3. Conclusions; Acknowledgments; References; Chapter Four: Estrogen Hormone Biology; 1. Introduction; 2. Cell Mechanisms; 3. Uterine Estrogen Response; 3.1. Genetic Control of Estrogen Responses; 3.2. ER[alpha] Mutations Demonstrate Uterine Mechanisms; 3.3. Tethered Pathway Analysis Using DNA-Binding Deficient ER[alpha] Mutants; 3.4. Analysis of AF-1- and AF-2-Mediated Responses; 3.5. Analysis of Biological Impact of Membrane-Initiated Signaling; 3.6. ER[beta] Does Not Impact Uterine Responses
• 3.7. Importance of ER[alpha] to Uterine Function Informs Mechanisms of Disease4. ER in the Ovary; 4.1. Ovarian Phenotypes of ER[alpha] Mutant Mice; 4.2. Ovary-Specific ER[alpha] Knockouts; 4.3. Ovarian Phenotypes of ER[beta] Mutant Mice; 4.4. Role of ER[beta] Signaling in Granulosa Cells; 4.5. Ovarian Phenotypes of ER[alpha] and ER[beta] Compound Mutant Mice; 4.6. Ovarian Phenotypes in Mice Lacking Estradiol Synthesis; 5. ER in Metabolism; 5.1. Metabolic Phenotype of ER[alpha] Knockout Mice; 5.2. Physiological Role of ER[alpha] Transactivation Domains in Metabolism; 5.3. Phenotype of ER[alpha] DNA-Binding Domain Mutant Mice in Metabolism
• Front cover; Nuclear Receptors in Development and Disease; Copyright; Contents; Contributors; Preface; Chapter One: Evolution of Nuclear Receptors and Ligand Signaling: Toward a Soft Key-Lock Model?; 1. Introduction; 2. The Ligand-Receptor Couple for NRs; 3. NR Diversification During Animal Evolution; 4. Evolution of Ligand Binding; 5. Alternative Ligands; 6. Generalization; References; Chapter Two: The Function and Evolution of Nuclear Receptors in Insect Embryonic Development; 1. Introduction: Nuclear Receptor Structure and Function; 2. Roles of NRs in Drosophila Embryonic Development
• 2.1. Nuclear Receptors and Early Patterning Mechanisms2.2. Functions of NRs During Neurogenesis; 2.3. A Cascade of NR Activity in Response to Ecdysone Mediates Mid-Embryogenesis Morphogenetic Movements and Recalibrates ...; 2.4. Functions of NRs in Morphogenesis and Maturation of Metabolic Organs; 2.5. Other NR Functions During Organogenesis; 2.6. Future Directions; 3. Functional Analysis of NRs in Nonmodel Insects; 3.1. Insects Are the Most Diverse Group on the Planet; 3.2. Genomic Inventory of NRs Across Insect Species; 3.3. Functional Studies of NRs in Emerging Insect Model Systems